Almutairi Yousef, Al-Sabah Humoud, Mosbeh Alsadat
Dermatology, Al Jahra Hospital, Al Jahra, KWT.
Dermatopathology, As'ad Al-Hamad Dermatology Center, Kuwait City, KWT.
Cureus. 2025 Aug 21;17(8):e90699. doi: 10.7759/cureus.90699. eCollection 2025 Aug.
Granular cell tumor (GCT), also known as Abrikossoff tumor, is an uncommon clinical entity derived from Schwann cells. Most are found in the oral cavity, especially the tongue. However, in this case, a rare clinical presentation occurred on the vulva of a young female patient, who presented with a progressively enlarged solitary nodule on her left labia majora. Histological examination showed a nonencapsulated tumor in the dermis, composed of large cells with abundant granular cytoplasm. Immunohistochemical staining revealed strong expression of S100 by tumor cells. Based on histopathological results, the vulvar tumor has been completely resected under local anesthesia with clear surgical margins of 0.5 cm. The patient has shown no tumor recurrence after six months following the surgery. In short, we think that GCT should be considered as one of the differential diagnosis of a solitary genital tumor at young ages.
颗粒细胞瘤（GCT），也称为阿布里科索夫瘤，是一种源自施万细胞的罕见临床实体。大多数发生在口腔，尤其是舌头。然而，在本病例中，一名年轻女性患者的外阴出现了罕见的临床表现，她的左侧大阴唇有一个逐渐增大的孤立结节。组织学检查显示真皮内有一个无包膜的肿瘤，由具有丰富颗粒状细胞质的大细胞组成。免疫组织化学染色显示肿瘤细胞强烈表达S100。根据组织病理学结果，在外阴局部麻醉下完整切除肿瘤，手术切缘清晰，达0.5厘米。术后六个月患者未出现肿瘤复发。简而言之，我们认为颗粒细胞瘤应被视为年轻患者孤立性生殖器肿瘤的鉴别诊断之一。
