A Distinct Clinical Entity of Invasive Cardiac Aspergillosis: Not the Heart Valves This Time.

Invasive aspergillosis (IA) is a life-threatening infection that mainly affects immunocompromised hosts. Cardiac involvement is rare but can be the sole presentation of IA. It is associated with a high mortality rate and mostly occurs in patients with pre-existing cardiac disease. It can also be seen in immunocompetent patients with a structurally normal heart. The reported cases of cardiac involvement are usually due to infectious endocarditis (IE) caused by species (most commonly ). However, there is limited data on non-valvular cardiac aspergillosis (NVCA). We reviewed 67 cases of NVCA published between 1950-2024 and reported an additional case from our institution involving a 48-year-old female with kyphoscoliosis diagnosed with pericarditis.