Al Khouri Zaid, Smeltzer Hunter, Al Qura'an Anood, Khan Mohammad H, Malek Alexandre E
Department of Medicine, Division of Infectious Diseases, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA.
J Fungi (Basel). 2025 Jun 26;11(7):486. doi: 10.3390/jof11070486.
Invasive aspergillosis (IA) is a life-threatening infection that mainly affects immunocompromised hosts. Cardiac involvement is rare but can be the sole presentation of IA. It is associated with a high mortality rate and mostly occurs in patients with pre-existing cardiac disease. It can also be seen in immunocompetent patients with a structurally normal heart. The reported cases of cardiac involvement are usually due to infectious endocarditis (IE) caused by species (most commonly ). However, there is limited data on non-valvular cardiac aspergillosis (NVCA). We reviewed 67 cases of NVCA published between 1950-2024 and reported an additional case from our institution involving a 48-year-old female with kyphoscoliosis diagnosed with pericarditis.
侵袭性曲霉病（IA）是一种危及生命的感染，主要影响免疫功能低下的宿主。心脏受累罕见，但可能是IA的唯一表现形式。它与高死亡率相关，且大多发生在已有心脏疾病的患者中。在心脏结构正常的免疫功能正常患者中也可见到。报道的心脏受累病例通常是由特定菌种（最常见的是）引起的感染性心内膜炎（IE）所致。然而，关于非瓣膜性心脏曲霉病（NVCA）的数据有限。我们回顾了1950年至2024年间发表的67例NVCA病例，并报告了我们机构的另外一例病例，该病例涉及一名48岁患有脊柱侧弯的女性，被诊断为心包炎。
