实验性自身免疫性脑脊髓炎。用溴化氰和胰蛋白酶消化人髓磷脂碱性蛋白。
Experimental autoimmune encephalomyelitis. Digestion of basic protein of human myelin with cyanogen bromide and trypsin.
作者信息
Carnegie P R, McPherson T A, Robson G S
出版信息
Immunology. 1970 Jul;19(1):55-63.
Abstract
From a cyanogen bromide digest of the encephalitogenic basic protein of human brain a polypeptide—derived from the N-terminal end of the protein—was isolated and shown to induce experimental autoimmune encephalomyelitis. At low doses this peptide induced typical histological lesions unaccompanied by clinical symptoms and humoral antibody. Digestion of the protein with trypsin did not destroy its encephalitogenic activity. The basic protein of human myelin contains more than one encephalitogenic determinant.
摘要
从人脑致脑炎碱性蛋白的溴化氰消化产物中，分离出一种源自该蛋白N末端的多肽，并证明其可诱发实验性自身免疫性脑脊髓炎。低剂量时，这种肽可诱发典型的组织学损伤，但无临床症状和体液抗体。用胰蛋白酶消化该蛋白不会破坏其致脑炎活性。人髓磷脂碱性蛋白含有不止一个致脑炎决定簇。
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