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螺旋藻对甲氨蝶呤诱导的大鼠雄性生育力及氧化应激的改善作用。

Ameliorative effect of spirulina on methotrexate-induced male fertility and oxidative stress in rats.

作者信息

Salah Noran Ibrahim, Abd El-Aziz Reda M, Elnabtity Sameh, Darwish Wageh Sobhy

机构信息

Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

出版信息

Open Vet J. 2025 Jun;15(6):2532-2539. doi: 10.5455/OVJ.2025.v15.i6.25. Epub 2025 Jun 30.

DOI:10.5455/OVJ.2025.v15.i6.25
PMID:40989643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12451120/
Abstract

BACKGROUND

Methotrexate is a chemotherapy drug that is used despite having several toxic effects. Spirulina is commonly consumed as a food supplement because of its antioxidant, antiinflammatory, and other beneficial effects. Aim: The present study was conducted to investigate the adverse effects of MTX on male sex hormones and subsequently its effects on oxidant/antioxidant status. The ameliorative effects of spirulina against such MTX-induced adverse effects were also evaluated.

METHODS

Forty male rats were randomly divided into four groups: control, spirulina, MTX, and MTX + spirulina groups. The levels of testosterone (free and total), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin hormone were evaluated as biochemical markers of MTX-induced infertility. Malondialdehyde (MDA) and total antioxidant capacity (TAC) levels were assayed in liver tissue as oxidative stress markers.

RESULTS

The results obtained from the current study showed that Spirulina improved the adverse effects of MTX on testosterone (free and total), LH, FSH, MDA, and TAC.

CONCLUSIONS

The current study indicated that spirulina can be used to ameliorate MTX-induced adverse effects on male infertility and oxidative stress.

摘要

背景

甲氨蝶呤是一种化疗药物，尽管有多种毒性作用仍被使用。螺旋藻因其抗氧化、抗炎及其他有益作用，常作为食品补充剂食用。目的：本研究旨在探讨甲氨蝶呤对男性性激素的不良影响及其对氧化/抗氧化状态的影响。同时评估螺旋藻对甲氨蝶呤所致这些不良影响的改善作用。

方法

将40只雄性大鼠随机分为四组：对照组、螺旋藻组、甲氨蝶呤组和甲氨蝶呤+螺旋藻组。评估睾酮（游离和总睾酮）、黄体生成素（LH）、卵泡刺激素（FSH）和催乳素的水平，作为甲氨蝶呤所致不育的生化指标。测定肝组织中丙二醛（MDA）和总抗氧化能力（TAC）水平，作为氧化应激指标。

结果

本研究结果表明，螺旋藻改善了甲氨蝶呤对睾酮（游离和总睾酮）、LH、FSH、MDA和TAC的不良影响。

结论

本研究表明，螺旋藻可用于改善甲氨蝶呤对男性不育和氧化应激的不良影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/7d1e8a257801/OpenVetJ-15-6-2532-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/d0105d33d2f1/OpenVetJ-15-6-2532-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/f0cc1edb7202/OpenVetJ-15-6-2532-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/fa53521a22a3/OpenVetJ-15-6-2532-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/2a1dafb3ecd0/OpenVetJ-15-6-2532-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/806672167bd1/OpenVetJ-15-6-2532-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/61f23f14a98c/OpenVetJ-15-6-2532-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/7d1e8a257801/OpenVetJ-15-6-2532-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/d0105d33d2f1/OpenVetJ-15-6-2532-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/f0cc1edb7202/OpenVetJ-15-6-2532-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/fa53521a22a3/OpenVetJ-15-6-2532-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/2a1dafb3ecd0/OpenVetJ-15-6-2532-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/806672167bd1/OpenVetJ-15-6-2532-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/61f23f14a98c/OpenVetJ-15-6-2532-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/12451120/7d1e8a257801/OpenVetJ-15-6-2532-g007.jpg

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Anticancer Drugs. 2022 Jan 1;33(1):75-79. doi: 10.1097/CAD.0000000000001125.
2
Antioxidant-Based Therapies in Male Infertility: Do We Have Sufficient Evidence Supporting Their Effectiveness?基于抗氧化剂的男性不育治疗方法：我们是否有足够证据支持其有效性？
Antioxidants (Basel). 2021 Feb 2;10(2):220. doi: 10.3390/antiox10020220.
3
Ameliorating effects of agomelatine on testicular and epididymal damage induced by methotrexate in rats.
阿戈美拉汀对甲氨蝶呤诱导的大鼠睾丸和附睾损伤的改善作用。
J Biochem Mol Toxicol. 2020 Mar;34(3):e22445. doi: 10.1002/jbt.22445. Epub 2020 Jan 23.
4
Donor lymphocyte infusion and methotrexate for immune recovery after T-cell depleted haploidentical transplantation.供者淋巴细胞输注和甲氨蝶呤用于 T 细胞耗竭的单倍体相合移植后的免疫恢复。
Am J Hematol. 2018 Feb;93(2):169-178. doi: 10.1002/ajh.24949. Epub 2017 Nov 17.
5
Beneficial effect of erdosteine on methotrexate-induced testicular toxicity in mice.厄多司坦对甲氨蝶呤诱导的小鼠睾丸毒性的有益作用。
Toxicol Ind Health. 2010 Aug;26(7):433-8. doi: 10.1177/0748233710369666. Epub 2010 May 26.
6
Ergogenic and antioxidant effects of spirulina supplementation in humans.螺旋藻补充对人体的促效和抗氧化作用。
Med Sci Sports Exerc. 2010 Jan;42(1):142-51. doi: 10.1249/MSS.0b013e3181ac7a45.
7
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Toxicol In Vitro. 2008 Sep;22(6):1496-502. doi: 10.1016/j.tiv.2008.05.004. Epub 2008 May 20.
8
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9
Aging and the brown Norway rat leydig cell antioxidant defense system.衰老与棕色挪威大鼠睾丸间质细胞抗氧化防御系统
J Androl. 2006 Mar-Apr;27(2):240-7. doi: 10.2164/jandrol.05075. Epub 2005 Nov 22.
10
Comparative analysis of the protective effects of melatonin and caffeic acid phenethyl ester (CAPE) on mobile phone-induced renal impairment in rat.褪黑素和咖啡酸苯乙酯（CAPE）对大鼠手机诱导的肾损伤保护作用的比较分析
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