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Gross and ultrastructural observations on lesions produced by intradermal injection of human C3a in man.

作者信息

Lepow I H, Willms-Kretschmer K, Patrick R A, Rosen F S

出版信息

Am J Pathol. 1970 Oct;61(1):13-23.

PMID:4099033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2047377/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5e/2047377/46ade54c0eb7/amjpathol00416-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5e/2047377/1ed573e2ab9b/amjpathol00416-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5e/2047377/1876df2d2f9f/amjpathol00416-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5e/2047377/46ade54c0eb7/amjpathol00416-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5e/2047377/1ed573e2ab9b/amjpathol00416-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5e/2047377/1876df2d2f9f/amjpathol00416-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be5e/2047377/46ade54c0eb7/amjpathol00416-0026-a.jpg

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Gross and ultrastructural observations on lesions produced by intradermal injection of human C3a in man.对人皮内注射人C3a所产生病变的大体及超微结构观察。
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2
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A naturally hypersensitive porcine model may help understand the mechanism of COVID-19 mRNA vaccine-induced rare (pseudo) allergic reactions: complement activation as a possible contributing factor.一种天然超敏的猪模型可能有助于理解 COVID-19 mRNA 疫苗引起的罕见（类）过敏反应的机制：补体激活可能是一个促成因素。
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本文引用的文献

1
Studies on inflammation. 1. The effect of histamine and serotonin on vascular permeability: an electron microscopic study.炎症研究。1. 组胺和血清素对血管通透性的影响：一项电子显微镜研究。
J Biophys Biochem Cytol. 1961 Dec;11(3):571-605. doi: 10.1083/jcb.11.3.571.
2
THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO.血清补体在体外白细胞趋化性中的作用
J Exp Med. 1965 Aug 1;122(2):327-46. doi: 10.1084/jem.122.2.327.
3
COMPLEMENT AS A MEDIATOR OF INFLAMMATION. ENHANCEMENT OF VASCULAR PERMEABILITY BY PURIFIED HUMAN C'1 ESTERASE.
蚊虫唾液中的补体抑制剂：结构与作用机制。
J Biol Chem. 2021 Jan-Jun;296:100083. doi: 10.1074/jbc.RA120.015230. Epub 2020 Nov 24.
4
The Anaphylatoxin C3a Receptor Expression on Human M2 Macrophages Is Down-Regulated by Stimulating the Histamine H4 Receptor and the IL-4 Receptor.组胺 H4 受体和白细胞介素 4 受体刺激可下调人 M2 巨噬细胞上的过敏毒素 C3a 受体表达。
J Innate Immun. 2018;10(4):349-362. doi: 10.1159/000490426. Epub 2018 Jul 20.
5
The pathophysiology of anaphylaxis.过敏反应的病理生理学。
J Allergy Clin Immunol. 2017 Aug;140(2):335-348. doi: 10.1016/j.jaci.2017.06.003.
6
Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice.肥大细胞过敏毒素受体表达可增强小鼠 IgE 依赖性皮肤炎症。
J Allergy Clin Immunol. 2013 Feb;131(2):541-8.e1-9. doi: 10.1016/j.jaci.2012.05.009. Epub 2012 Jun 22.
7
Effects of two types of cobra venom factor on porcine complement activation and pulmonary artery pressure.两种眼镜蛇毒因子对猪补体激活及肺动脉压的影响。
Clin Exp Immunol. 1989 Nov;78(2):299-306.
8
Mast cell-dependent effector pathways and cutaneous bullous disorders.肥大细胞依赖性效应途径与皮肤大疱性疾病。
Springer Semin Immunopathol. 1981 Jun;4(1):65-72. doi: 10.1007/BF01891886.
9
Potentiation of the anaphylatoxins in vivo using an inhibitor of serum carboxypeptidase N (SCPN). I. Lethality and pathologic effects on pulmonary tissue.使用血清羧肽酶N（SCPN）抑制剂在体内增强过敏毒素。I. 对肺组织的致死性和病理影响。
Am J Pathol. 1983 Jul;112(1):48-60.
10
The role of complement in phototoxic reactions.补体在光毒性反应中的作用。
Springer Semin Immunopathol. 1981;4(3):209-19. doi: 10.1007/BF01892178.
补体作为炎症介质。纯化的人C1酯酶对血管通透性的增强作用。
J Exp Med. 1963 Nov 1;118(5):681-98. doi: 10.1084/jem.118.5.681.
4
Complement as a mediator of inflammation. 3. Purification of the activity with anaphylatoxin properties generated by interaction of the first four components of complement and its identification as a cleavage product of C'3.补体作为炎症介质。3. 具有过敏毒素特性的活性物质的纯化，该活性物质由补体前四种成分相互作用产生，并鉴定为C'3的裂解产物。
J Exp Med. 1967 Dec 1;126(6):1027-48. doi: 10.1084/jem.126.6.1027.
5
Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and description of an anaphylatoxin inactivator of human serum.分离出含有过敏毒素和趋化活性的人补体第三成分的一个片段（C3a），并描述一种人血清过敏毒素灭活剂。
J Exp Med. 1969 May 1;129(5):1109-30. doi: 10.1084/jem.129.5.1109.
6
Ischemia of the skin. Electron microscopic study of vascular injury.皮肤缺血。血管损伤的电子显微镜研究。
Am J Pathol. 1969 Mar;54(3):327-53.
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The derivation of two distinct anaphylatoxin activities from the third and fifth components of human complement.从人补体的第三和第五成分中衍生出两种不同的过敏毒素活性。
J Exp Med. 1968 Feb 1;127(2):371-86. doi: 10.1084/jem.127.2.371.
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A plasmin-split fragment of C'3 as a new chemotactic factor.补体C3的纤溶酶裂解片段作为一种新的趋化因子。
J Exp Med. 1967 Aug 1;126(2):189-206. doi: 10.1084/jem.126.2.189.
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Release of histamine from rat mast cells: a comparison of the effects of 48-80 and two antigen systems.大鼠肥大细胞组胺的释放：48-80与两种抗原系统作用的比较
Fed Proc. 1969 Sep-Oct;28(5):1716-20.
10
The enhancement of bacterial phagocytosis by serum. The role of complement components and two cofactors.血清对细菌吞噬作用的增强。补体成分和两种辅助因子的作用。
J Exp Med. 1969 Jun 1;129(6):1275-90. doi: 10.1084/jem.129.6.1275.