Townsend Liam, Herraghty Fiona, Brennan Seán, Grant Conor, Wang Wenzhou, Moriarty Anne, Lynagh Yvonne, Clancy Lorraine, Power Antoinette, Crowley Brendan, Norris Suzanne, Shields Darragh, Bergin Colm
Department of Infectious Diseases, St James's Hospital, Dublin, Ireland.
Department of Clinical Medicine, Trinity College Dublin, Dublin, Ireland.
Open Forum Infect Dis. 2025 Sep 11;12(9):ofaf547. doi: 10.1093/ofid/ofaf547. eCollection 2025 Sep.
Bloodborne viruses (BBV) such as hepatitis B (HBV), hepatitis C (HCV), and HIV pose significant personal and public health risks. Screening and linkage to treating services are important tools in treatment and preventing onward transmission. This study reports outcomes of 10 years of an opt-out BBV screening program in a large urban emergency department (ED).
Starting in July 2015, ED patients undergoing phlebotomy were offered routine BBV screening. We examine acceptance of screening, characteristics of new diagnoses, and onward linkage to care 10 years after program implementation. We also investigate factors associated with new viremic HCV diagnoses within this cohort to inform future service development.
Over the 10-year period, acceptance of BBV screening among phlebotomized patients was high (81%). There was no significant change in rates of new diagnoses of HIV, HBV, or HCV, but there was a significant reduction in polymerase chain reaction-positive HCV diagnoses. Linkage to care was high (96% HIV, 89% HBV, 95% HCV). Polymerase chain reaction-positive HCV was associated with people who inject drugs and being discharged directly from the ED.
BBV screening in the ED demonstrates sustained acceptability, with a steady rate of new diagnoses detected. It provides high levels of linkage to care. It also identifies active HCV within a population of people who inject drugs attending the ED who are discharged directly without needing admission.
乙肝病毒(HBV)、丙肝病毒(HCV)和艾滋病毒等血源性病原体对个人和公众健康构成重大风险。筛查以及与治疗服务的衔接是治疗和预防病毒传播的重要手段。本研究报告了在一家大型城市急诊科开展的为期10年的主动式血源性病原体筛查项目的成果。
从2015年7月开始,为在急诊科接受静脉穿刺采血的患者提供常规血源性病原体筛查。我们研究了项目实施10年后筛查的接受情况、新确诊病例的特征以及与后续治疗的衔接情况。我们还调查了该队列中与新发病毒血症丙肝确诊病例相关的因素,以为未来的服务发展提供参考。
在这10年期间,接受静脉穿刺采血的患者对血源性病原体筛查的接受度较高(81%)。艾滋病毒、乙肝病毒或丙肝病毒的新确诊率没有显著变化,但聚合酶链反应阳性的丙肝确诊病例显著减少。与后续治疗的衔接情况良好(艾滋病毒为96%,乙肝病毒为89%,丙肝病毒为95%)。聚合酶链反应阳性的丙肝与注射毒品者以及直接从急诊科出院的患者有关。
在急诊科进行血源性病原体筛查显示出持续的可接受性,新确诊病例的检出率稳定。它提供了高水平的后续治疗衔接。它还在直接出院而无需住院的急诊科注射毒品人群中识别出了活跃的丙肝病毒感染病例。