Yao Zi-Ang, Xu Ling, Liu Yu, Wu Hai-Ge
College of Life Science, Dalian Minzu University, Dalian, Liaoning, China.
College of Life and Health, Dalian University, Dalian, Liaoning, China.
Microbiol Spectr. 2025 Sep 25:e0283224. doi: 10.1128/spectrum.02832-24.
Abnormal lipid metabolism is manifested in a variety of metabolic diseases. In recent years, studies have shown that the pathogenesis of these disorders is closely associated with the gut microbiota. Marine algae polysaccharides, such as sodium alginate and its oligosaccharides, can reduce blood lipids and improve lipid metabolism to reduce body weight. Polysaccharides are difficult to be absorbed by the human body due to their large molecular weight, which limits their application in the field of medicine and food. In this study, two kinds of marine algae polysaccharides and their oligosaccharides were used to investigate their effects on body weight, lipid metabolism, inflammatory factors, and intestinal health and microbiota in high-fat diet mice. The results showed that after feeding a high-fat diet, the mice's body weight and serum lipids were increased. The formation of fat droplets was observed in the liver cells. Small intestinal microvilli were destroyed and showed obvious accumulation of epithelial cells. After feeding mice with sodium alginate, agar, and its oligosaccharides, the level of body weight and the pathological damage of the liver and intestine were relieved. Gut microbiota analysis showed that two kinds of polysaccharides and their oligosaccharides could improve the composition of gut microbiota at the phylum and genus level, increase the abundance of and , and reduce the abundance of opportunistic pathogenic bacteria. This study provides a direction for the prevention and treatment of lipid metabolic diseases and ideas for the development of marine functional food.IMPORTANCEAbnormal lipid metabolism is manifested in a variety of metabolic diseases. Marine algae polysaccharides, such as sodium alginate and its oligosaccharides, can reduce blood lipids and improve lipid metabolism to reduce body weight. Polysaccharides are difficult to absorb by the human body due to their large molecular weight, which limits their application in the field of medicine and food. After feeding mice with sodium alginate, agar, and its oligosaccharides, the level of body weight, serum lipids, inflammatory factors, and the pathological damage of liver and intestine were relieved. Gut microbiota analysis showed that two kinds of polysaccharides and their oligosaccharides could improve the composition of gut microbiota at the phylum and genus level, increase the abundance of and , and reduce the abundance of harmful bacteria. This study provides a direction for the prevention and treatment of lipid metabolic diseases and ideas for the development of marine functional food.
脂质代谢异常表现在多种代谢性疾病中。近年来，研究表明这些疾病的发病机制与肠道微生物群密切相关。海藻多糖，如海藻酸钠及其寡糖，可以降低血脂、改善脂质代谢以减轻体重。由于多糖分子量较大，难以被人体吸收，这限制了它们在医药和食品领域的应用。在本研究中，使用了两种海藻多糖及其寡糖来研究它们对高脂饮食小鼠体重、脂质代谢、炎症因子以及肠道健康和微生物群的影响。结果表明，高脂饮食喂养后，小鼠体重和血脂升高。在肝细胞中观察到脂肪滴的形成。小肠微绒毛遭到破坏，上皮细胞出现明显堆积。给小鼠喂食海藻酸钠、琼脂及其寡糖后，体重水平以及肝脏和肠道的病理损伤得到缓解。肠道微生物群分析表明，两种多糖及其寡糖可以在门和属水平上改善肠道微生物群的组成，增加[具体菌属1]和[具体菌属2]的丰度，并降低机会性致病菌的丰度。本研究为脂质代谢疾病的防治提供了方向，也为海洋功能性食品的开发提供了思路。
脂质代谢异常表现在多种代谢性疾病中。海藻多糖，如海藻酸钠及其寡糖，可以降低血脂、改善脂质代谢以减轻体重。由于多糖分子量较大，难以被人体吸收，这限制了它们在医药和食品领域的应用。给小鼠喂食海藻酸钠、琼脂及其寡糖后，体重、血脂、炎症因子水平以及肝脏和肠道的病理损伤得到缓解。肠道微生物群分析表明，两种多糖及其寡糖可以在门和属水平上改善肠道微生物群的组成，增加[具体菌属1]和[具体菌属2]的丰度，并降低有害菌的丰度。本研究为脂质代谢疾病的防治提供了方向，也为海洋功能性食品的开发提供了思路。
