爱尔- SERI高度近视成人队列研究中近视性牵引性黄斑病变的特征
Characteristics of Myopic Traction Maculopathy in the Aier-SERI High Myopia Adult Cohort Study.
作者信息
Cheong Kai-Xiong, Jiang Yanfeng, Htoon Hla Myint, Pan Wei, Foo Li-Lian, Hu Ziqi, Chen Ling, Ang Sophie, Lamoureux Ecosse L, Hoang Quan V, Saw Seang-Mei, Lan Weizhong
机构信息
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Aier Academy of Ophthalmology, Central South University, Changsha, Hunan, People's Republic of China.
出版信息
Ophthalmol Sci. 2025 Jul 24;5(6):100894. doi: 10.1016/j.xops.2025.100894. eCollection 2025 Nov-Dec.
PURPOSE
To describe the prevalence, clinical characteristics, associations, and visual outcomes of myopic traction maculopathy (MTM), which was defined by the presence of retinoschisis (RS), macular holes (MHs), or foveal retinal detachment (RD), in an adult high myope cohort in Changsha, China.
DESIGN
A cross-sectional study.
PARTICIPANTS
Chinese adults with high myopia (defined as spherical equivalent [SE] less than or equal to -5 diopters [D]) in the Aier-Singapore Eye Research Institute High Myopia Adult Cohort Study, which is a prospective population-based study.
METHODS
Swept-source OCT was performed to detect RS, MH, and foveal RD. Multivariable generalized estimating equation analyses were performed to assess associations of MTM and the impact of MTM on best-corrected visual acuity (BCVA).
MAIN OUTCOME MEASURES
Prevalence, clinical characteristics, associations, and visual outcomes of MTM.
RESULTS
Of 437 participants (839 eyes), MTM was observed in 20 participants with a prevalence of 4.6% (by participants) or in 24 eyes (with a prevalence of 2.9%; by eyes). Overall, the whole cohort (64.7% female) had a mean age of 42.9 ± 7.2 years, an SE of -9.5 ± 4.4 D, and an axial length (AL) of 27.3 ± 1.9 mm. Retinoschisis was the most common lesion (91.7%; 22/24 eyes with MTM). In the multivariable analysis, the prevalence of MTM was associated with a more myopic SE (odds ratio [OR]: 1.09; 95% confidence interval [CI]: 1.01-1.18; = 0.03), longer AL (OR: 1.30; 95% CI: 1.03-1.65; = 0.03), myopic macular degeneration (MMD) (OR: 12.77; 95% CI: 3.18-51.24; < 0.001), and older age (OR: 1.06; 95% CI: 1.01-1.11; = 0.01). In the multivariable analysis, the prevalence of MTM was also associated with poorer BCVA (beta coefficient: -0.07; 95% CI: -0.13 to -0.01; < 0.01).
CONCLUSIONS
The prevalence of MTM was 4.6% in an adult high myope cohort. Associations with MTM include more myopic SE, longer AL, MMD, and older age. Myopic traction maculopathy is associated with poorer vision.
FINANCIAL DISCLOSURES
The authors have no proprietary or commercial interest in any materials discussed in this article.
目的
描述在中国长沙的一个成年高度近视队列中，近视性牵引性黄斑病变（MTM）的患病率、临床特征、相关性及视力预后，MTM定义为存在视网膜劈裂（RS）、黄斑裂孔（MHs）或黄斑中心凹视网膜脱离（RD）。
设计
一项横断面研究。
参与者
爱尔-新加坡眼研究所高度近视成年队列研究中的中国成年高度近视患者（定义为等效球镜度[SE]小于或等于-5屈光度[D]），这是一项基于人群的前瞻性研究。
方法
采用扫频光学相干断层扫描（OCT）检测RS、MH和黄斑中心凹RD。进行多变量广义估计方程分析，以评估MTM的相关性以及MTM对最佳矫正视力（BCVA）的影响。
主要观察指标
MTM的患病率、临床特征、相关性及视力预后。
结果
在437名参与者（839只眼）中，20名参与者观察到MTM，患病率为4.6%（按参与者计算），或在24只眼中观察到MTM（患病率为2.9%；按眼计算）。总体而言，整个队列（64.7%为女性）的平均年龄为42.9±7.2岁，SE为-9.5±4.4 D，眼轴长度（AL）为27.3±1.9 mm。视网膜劈裂是最常见的病变（91.7%；24只MTM眼中的22只）。在多变量分析中，MTM的患病率与更高度数的SE相关（比值比[OR]：1.09；95%置信区间[CI]：1.01-1.18；P = 0.03）、更长的AL（OR：1.30；95% CI：1.03-1.65；P = 0.03）、近视性黄斑变性（MMD）（OR：12.77；95% CI：3.18-51.24；P < 0.001）和年龄较大（OR：1.06；95% CI：1.01-1.11；P = 0.01）。在多变量分析中，MTM的患病率还与较差的BCVA相关（β系数：-0.07；95% CI：-0.13至-0.01；P < 0.01）。
结论
在一个成年高度近视队列中，MTM的患病率为4.6%。与MTM相关的因素包括更高度数的SE、更长的AL、MMD和年龄较大。近视性牵引性黄斑病变与视力较差相关。
财务披露
作者对本文讨论的任何材料均无所有权或商业利益。
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