Jakobsen Rasmus Kragh, Farver-Vestergaard Ingeborg, Løkke Anders
Department of Medicine, Lillebaelt Hospital, Vejle, Denmark.
Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Front Health Serv. 2025 Sep 10;5:1659295. doi: 10.3389/frhs.2025.1659295. eCollection 2025.
Smoking cessation remains among the most effective interventions for improving outcomes in patients with chronic obstructive pulmonary disease (COPD). Quitting smoking slows disease progression, reduces morbidity, improves quality of life and increases life expectancy. However, a substantial proportion of patients with COPD continue to smoke, and generic cessation strategies often fall short in this population. While most cessation research targets "healthy" smokers, individuals with COPD face additional challenges - including higher nicotine dependence and psychological comorbidities - that complicate quit attempts.
This mini-review summarises randomised controlled trials (RCTs) investigating smoking cessation interventions in COPD.
Our study reveals wide variability in the intensity, duration and components of interventions, with only a minority achieving long-term abstinence. Notably, two high-performing studies stand out for their comprehensive, long-term and individualised approaches. These findings suggest that success in smoking cessation for patients with COPD relies not only on the right intervention components but also on the construction, durability and sustained support.
To support and sustain smoking cessation among patients with COPD, multicomponent, high-intensity and long-duration interventions tailored to individual needs appear to be required, with an emphasis on ongoing support and frequent follow-up.
戒烟仍然是改善慢性阻塞性肺疾病（COPD）患者预后最有效的干预措施之一。戒烟可减缓疾病进展、降低发病率、提高生活质量并延长预期寿命。然而，相当一部分COPD患者仍继续吸烟，通用的戒烟策略在这一人群中往往效果不佳。虽然大多数戒烟研究针对的是“健康”吸烟者，但COPD患者面临额外的挑战，包括更高的尼古丁依赖和心理合并症，这使得戒烟尝试变得更加复杂。
本小型综述总结了调查COPD患者戒烟干预措施的随机对照试验（RCT）。
我们的研究表明，干预措施的强度、持续时间和组成部分存在很大差异，只有少数能实现长期戒烟。值得注意的是，两项表现出色的研究因其全面、长期和个性化的方法脱颖而出。这些发现表明，COPD患者戒烟的成功不仅取决于正确的干预组成部分，还取决于干预措施的构建、持续性和持续支持。
为了支持和维持COPD患者的戒烟，似乎需要针对个体需求的多成分、高强度和长期干预措施，重点是持续支持和频繁随访。
