Smallfield Jessica L, DeRouchey Joel M, Tokach Mike D, Woodworth Jason C, Goodband Robert D, Gaffield Katelyn N, Gebhardt Jordan T, Yao Robin, Guo Yitong
Department of Animal Sciences and Industry, College of Agriculture, Kansas State University, Manhattan, KS 66506-0201.
Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-0201.
J Anim Sci. 2025 Jan 4;103. doi: 10.1093/jas/skaf331.
A total of 360 weanling pigs (241 × 600, DNA; initially 5.4 ± 0.01 kg) were used to evaluate the effects of a hydrolyzed yeast product (HY) on growth performance, fecal dry matter (DM), and stress-relevant blood antioxidant criteria. Pens of pigs were randomly allotted to one of six dietary treatments in a generalized randomized block design with 5 pigs per pen and 12 pens per treatment. Pigs were blocked with 4 replications of light (4.3 ± 0.01 kg), medium (5.4 ± 0.01 kg), and heavy (6.5 ± 0.01 kg) weight pens per treatment. Diets were corn-soybean meal-based and consisted of a negative control (NC) diet, a positive control (PC) diet which was the NC diet + 55 mg/kg carbadox, the PC diet with 0.04% HY, and the NC diet with either 0.04%, 0.08%, or 0.12% HY. Linear and quadratic contrasts were tested within increasing levels of HY in diets without carbadox. The main effect of carbadox was evaluated by comparing the average of 0% and 0.04% HY in the presence and absence of carbadox. Treatment diets were fed in three phases from day 0 to 10 (phase 1), day 10 to 24 (phase 2), and day 24 to 45 (phase 3). On day 10 and 24, fecal samples were collected from the same three initially randomly selected pigs in each pen to determine fecal DM and fecal scores. Blood samples were collected on day 10 and 45 from the same representative pig in each pen for total antioxidant capacity (TAC) and superoxide dismutase (SOD). Overall (day 0 to 45), final weight increased (P < 0.05) while average daily gain (ADG) and average daily feed intake (ADFI) tended to increase (P < 0.10) for pigs fed diets containing carbadox compared to pigs fed diets without carbadox. Gain:feed ratio (G:F) increased (P = 0.017) when 0.04% HY was added to the negative and positive control diets. On day 10, increasing HY in diets without carbadox increased fecal DM (linear, P = 0.005). Additionally, pigs fed carbadox had increased (P < 0.05) fecal DM on day 10 and 24 compared to pigs not fed carbadox. There were no treatment differences observed on day 10 for TAC; however, TAC decreased (linear, P = 0.008) on day 45 as HY increased in the diet. Increasing HY tended to decrease (linear, P = 0.095) serum SOD activity on day 10 while no treatment differences were observed on day 45. In summary, pigs fed carbadox had increased overall ADG and fecal DM. Increasing HY inclusion did not affect growth performance; however, fecal DM was improved during the early nursery period. Additionally, feeding 0.04% HY improved overall G:F.
总共360头断奶仔猪（241×600，DNA；初始体重5.4±0.01千克）用于评估水解酵母产品（HY）对生长性能、粪便干物质（DM）以及与应激相关的血液抗氧化指标的影响。在广义随机区组设计中，将猪栏随机分配到六种日粮处理之一，每栏5头猪，每个处理12栏。每个处理的猪按体重分为轻（4.3±0.01千克）、中（5.4±0.01千克）、重（6.5±0.01千克）三组，每组4个重复。日粮以玉米 - 豆粕为基础，包括阴性对照（NC）日粮、阳性对照（PC）日粮（NC日粮 + 55毫克/千克卡巴氧）、含0.04% HY的PC日粮以及含0.04%、0.08%或0.12% HY的NC日粮。在不含卡巴氧的日粮中，随着HY水平升高，进行线性和二次对比试验。通过比较有无卡巴氧时0%和0.04% HY的平均值来评估卡巴氧的主要作用。从第0天到第10天（第1阶段）、第10天到第24天（第2阶段）以及第24天到第45天（第3阶段）分三个阶段饲喂处理日粮。在第10天和第24天，从每栏最初随机选取的相同三头猪采集粪便样本，以测定粪便DM和粪便评分。在第10天和第45天，从每栏相同的代表性猪采集血液样本，用于测定总抗氧化能力（TAC）和超氧化物歧化酶（SOD）。总体而言（第0天到第45天），与未饲喂卡巴氧日粮的猪相比，饲喂含卡巴氧日粮的猪最终体重增加（P<0.05），平均日增重（ADG）和平均日采食量（ADFI）有增加趋势（P<0.10）。当在阴性和阳性对照日粮中添加0.04% HY时，料重比（G:F）增加（P = 0.017）。在第10天，不含卡巴氧的日粮中增加HY会增加粪便DM（线性关系，P = 0.005）。此外，与未饲喂卡巴氧的猪相比，饲喂卡巴氧的猪在第10天和第24天粪便DM增加（P<0.05）。在第10天，TAC未观察到处理差异；然而，在第45天，随着日粮中HY增加，TAC降低（线性关系，P = 0.008）。在第10天，增加HY有降低血清SOD活性的趋势（线性关系，P = 0.095），而在第45天未观察到处理差异。总之，饲喂卡巴氧的猪总体ADG和粪便DM增加。增加HY添加量不影响生长性能；然而，在保育早期粪便DM得到改善。此外，饲喂0.04% HY可提高总体G:F。
