Hwang Jae Yeon, Han Sung Woo, Huh Seung Hee, Park So Hee, Park Sang Min, Park Jung Hoon
Department of Chemical and Biochemical Engineering, Dongguk University, Pildong-ro 1-gil, Jung-gu, Seoul 04620, Republic of Korea.
Membranes (Basel). 2025 Aug 26;15(9):251. doi: 10.3390/membranes15090251.
The application of ceramic membranes in hemodialysis modules remains underexplored, as prior investigations have primarily concentrated on flat-sheet samples or small-scale assessments. This study advances the field by fabricating AlO hollow fiber membranes, integrating them into a lab-scale module, and systematically evaluating the influence of sintering temperature on their structural characteristics, hemocompatibility, and dialysis performance. AlO hollow fiber membranes were prepared using a phase inversion method and then sintered at three different temperatures. All membranes exhibited superior protein adsorption behavior compared to conventional polymer-based membranes, which indicates higher biocompatibility. Furthermore, the amount of adsorbed protein decreased with increasing sintering temperature. This suggests that the amount of protein adsorption can be controlled by adjusting the heat treatment conditions. The lab-scale hemodialyzer integrated with a membrane sintered at 1200 °C achieved the fastest urea removal rate of approximately 90% in 2 h and reached a / value of 1.1 after 60 min, which is comparable to the performance of commercial polymer-based hemodialyzers.
陶瓷膜在血液透析模块中的应用仍未得到充分探索，因为先前的研究主要集中在平板样品或小规模评估上。本研究通过制造AlO中空纤维膜、将其集成到实验室规模的模块中，并系统评估烧结温度对其结构特性、血液相容性和透析性能的影响，推动了该领域的发展。采用相转化法制备AlO中空纤维膜，然后在三个不同温度下进行烧结。与传统的聚合物基膜相比，所有膜都表现出优异的蛋白质吸附行为，这表明其具有更高的生物相容性。此外，随着烧结温度的升高，吸附的蛋白质量减少。这表明可以通过调整热处理条件来控制蛋白质吸附量。集成了在1200℃烧结的膜的实验室规模血液透析器在2小时内实现了约90%的最快尿素清除率，60分钟后达到1.1的a/值，这与商业聚合物基血液透析器的性能相当。
