维持性血液透析患者体外循环中透析器几何形状对凝血激活的影响：前瞻性随机试验。
Effect of dialyzer geometry on coagulation activation in the extracorporeal circuit in maintenance hemodialysis patients: Prospective randomized trial.
机构信息
Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
出版信息
Ther Apher Dial. 2023 Aug;27(4):629-635. doi: 10.1111/1744-9987.13975. Epub 2023 Feb 19.
BACKGROUND AND OBJECTIVES
The coagulation cascade is activated during hemodialysis (HD) due to interaction of blood with the dialysis circuit. There is a paucity of data on the effect of the physical structure of the dialyzers on coagulation activation during HD. We conducted this study to compare the effect of Helixone FX80 versus Platinum H4 dialyzers on coagulation activation during HD.
METHODS
Twenty patients on maintenance HD were enrolled in this randomized prospective crossover study. Each patient was dialyzed using Helixone FX80 and Platinum H4 dialyzers. Serum thrombin-antithrombin complex (TAT) was measured before (T0h) and at the end (T4H) of HD.
RESULTS
The absolute changes of serum TAT were comparable with the two dialyzers (median [IQR]: 1.15 [0.65, 1.75] for Helixone FX80 vs. 1.15 [0.67, 2.05] for Platinum H4, p = 0.371).
CONCLUSION
Helixone FX80 and Platinum H4 dialyzers have similar effects on coagulation activation during HD.
背景与目的
血液与透析回路相互作用会导致血液透析（HD）过程中凝血级联反应被激活。然而，关于透析器的物理结构对 HD 过程中凝血激活的影响的数据却很少。我们开展了这项研究，旨在比较 Helixone FX80 与 Platinum H4 透析器对 HD 过程中凝血激活的影响。
方法
这项随机前瞻性交叉研究纳入了 20 名接受维持性 HD 的患者。每位患者均使用 Helixone FX80 和 Platinum H4 透析器进行透析。在 HD 开始前（T0h）和结束时（T4H）测量血清凝血酶-抗凝血酶复合物（TAT）。
结果
两种透析器的血清 TAT 绝对变化值相当（Helixone FX80 的中位数[IQR]：1.15[0.65, 1.75]，Platinum H4 的中位数[IQR]：1.15[0.67, 2.05]，p=0.371）。
结论
Helixone FX80 和 Platinum H4 透析器对 HD 过程中的凝血激活具有相似的影响。
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