Martín-Sánchez Joaquina, Requena Jose M, Gállego Montserrat, Jiménez Maribel, Molina Ricardo, Nguewa Paul, Morillas-Márquez Francisco, Pérez-Victoria José M, Monge-Maillo Begoña, Morales-Yuste Manuel, Marín Clotilde
Departamento de Parasitología, Universidad de Granada, 18071 Granada, Spain.
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Departamento de Biología Molecular, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
Trop Med Infect Dis. 2025 Sep 18;10(9):269. doi: 10.3390/tropicalmed10090269.
: Leishmaniasis, a vector-borne disease caused by the parasite , is a public health concern in Europe. Although Spain is an endemic country, it lacks a national surveillance network. To address this, the creation of a research and surveillance network is proposed, which would integrate data from various fields and enhance control and public health strategies. : The first objective is to gather epidemiological data on vectors, reservoirs, and transmission rates in Spain, with a particular focus on the role of dogs and wildlife as primary reservoirs. The plan includes establishing forums, databases, and specialised training programmes. The second objective is to improve case surveillance and reporting by establishing a comprehensive national registry. Implementing molecular diagnostics and bioinformatics tools will aid analysis of retrospective data and tracking of disease evolution. The third objective is to develop a standardised method for the molecular characterisation of , using techniques such as PCR and genomic sequencing to detect virulence and resistance patterns. Key actions include collecting isolates, sharing analytical tools and providing genomic training. The fourth objective is to identify new therapeutic targets in response to toxicity and resistance to current treatments by studying specific enzymes (FeSOD, HDAC), metabolic pathways, and natural products. Ultimately, establishing the Leishmaniasis Surveillance Network will support a "One Health" approach and promote interdisciplinary collaboration towards a national control plan. : We created the Working Group on Leishmaniasis funded by the Spanish Society of Tropical Medicine and International Health as a leishmaniasis forum for meetings and discussions on weaknesses and gaps we find in the knowledge and management of the infection based on the background of each academic and healthcare research group. : This study will promote the articulation of a Leishmaniasis Surveillance Network aiming to bring together the main stakeholders in the research and management of leishmaniasis in Spain.
利什曼病是一种由寄生虫引起的媒介传播疾病，在欧洲是一个公共卫生问题。尽管西班牙是该病的流行国家，但它缺乏国家监测网络。为解决这一问题，提议创建一个研究和监测网络，该网络将整合来自各个领域的数据，并加强控制和公共卫生战略。：第一个目标是收集西班牙有关媒介、宿主以及传播率的流行病学数据，特别关注狗和野生动物作为主要宿主的作用。该计划包括建立论坛、数据库和专门的培训项目。第二个目标是通过建立一个全面的国家登记处来改善病例监测和报告。实施分子诊断和生物信息学工具将有助于对回顾性数据进行分析，并追踪疾病的演变。第三个目标是开发一种用于利什曼原虫分子特征分析的标准化方法，使用PCR和基因组测序等技术来检测毒力和耐药模式。关键行动包括收集分离株、共享分析工具以及提供基因组培训。第四个目标是通过研究特定酶（铁超氧化物歧化酶、组蛋白去乙酰化酶）、代谢途径和天然产物，来确定针对当前治疗的毒性和耐药性的新治疗靶点。最终，建立利什曼病监测网络将支持“同一健康”方法，并促进跨学科合作以制定国家控制计划。：我们成立了由西班牙热带医学和国际卫生协会资助的利什曼病工作组，作为一个利什曼病论坛，用于基于每个学术和医疗研究小组的背景，就我们在感染知识和管理方面发现的弱点和差距进行会议和讨论。：本研究将促进利什曼病监测网络的构建，旨在汇聚西班牙利什曼病研究和管理的主要利益相关者。
