鲁索替尼成功治疗自体干细胞移植后患者的类固醇难治性胃肠道移植物抗宿主病：一例报告
Successful treatment of steroid-refractory gastrointestinal GVHD with ruxolitinib in a patient after autologous stem cell transplantation: a case report.
作者信息
Yahya Duha, Ayran Mona, Özden Ferhat, Abedi Amir Hossein, Kaya Sureyya Yiğit, Beköz Hüseyin Saffet, Çakır Aslı, Maral Senem, Kaynar Leylagül
机构信息
International School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Department of Pathology, International School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
出版信息
Int J Hematol. 2025 Sep 26. doi: 10.1007/s12185-025-04073-2.
INTRODUCTION
Graft-versus-host disease (GVHD) is a serious immune reaction that usually occurs after allogenic stem cell transplants and can affect organs, such as skin, gastrointestinal (GI) system, and liver. The development of GVHD after autologous stem cell transplantation (auto-SCT) is rarely observed and only a few cases have been reported in the literature.
CASE PRESENTATION
A 21-year-old patient who underwent auto-SCT for neurofibromatosis type 1 developed severe GI-GVHD confirmed by histopathology. She responded inadequately to systemic corticosteroids, indicating steroid-refractory disease. Subsequent addition of the JAK1/2 inhibitor ruxolitinib resulted in rapid clinical improvement.
CONCLUSION
This clinical case scenario suggests that ruxolitinib could be a treatment option in rare cases of GVHD following auto-SCT.
引言
移植物抗宿主病（GVHD）是一种严重的免疫反应，通常发生在异基因干细胞移植后，可累及皮肤、胃肠道（GI）系统和肝脏等器官。自体干细胞移植（auto-SCT）后发生GVHD的情况很少见，文献中仅报道了少数病例。
病例报告
一名因1型神经纤维瘤病接受auto-SCT的21岁患者经组织病理学证实发生了严重的胃肠道GVHD。她对全身皮质类固醇治疗反应不佳，提示为类固醇难治性疾病。随后加用JAK1/2抑制剂芦可替尼后临床症状迅速改善。
结论
该临床病例表明，对于auto-SCT后罕见的GVHD病例，芦可替尼可能是一种治疗选择。
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