Witte Felix, Weisshaar Elke, Metz Martin, Koschmieder Steffen, Isfort Susanne, Kremer Andreas E, Griesshammer Martin, Royeck Svenja, Ständer Sonja, Zeidler Claudia
Department of Dermatology, Section Pruritus Medicine and Center for Chronic Pruritus, University Hospital Münster, Von-Esmarch-Strasse 58, 48149, Münster, Germany.
Division of Occupational Dermatology, Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
Dermatol Ther (Heidelb). 2025 Sep 26. doi: 10.1007/s13555-025-01548-2.
Aquagenic pruritus (AP) is an underrecognized condition in which patients perceive itch following contact with water on clinically non-lesional skin. AP is frequent in patients suffering from myeloproliferative neoplasms (MPN) such as polycythemia vera and may manifest several years prior to MPN diagnosis. To date, there is no validated patient-reported outcome measure (PROM) assessing AP and its association with MPN.
In this multiphase study, eight questions relevant to AP were developed and validated in 77 patients with AP and 50 patients with chronic non-aquagenic pruritus (CP). After reduction to those questions relevant for distinguishing between AP with and without MPN, the resulting questionnaire was validated in 76 patients with AP (37 with MPN) and 76 with CP. The predictive power of the questionnaire's score was retrospectively tested in the first cohort.
Four key questions were identified as central to differentiating MPN in AP, forming the basis of the AP questionnaire (APQ). Sensitivity and specificity of the score reached 97.3% and 79.5%, respectively. The APQ classified five patients with AP with MPN who were diagnosed with MPN at a later stage.
APQ is the first validated PROM for patients with AP, detecting a potential relationship to MPN with high sensitivity. APQ is a useful addition to standard of care in patients suffering from AP, potentially shortening the delay of MPN diagnosis.
German Clinical Trials Registry, DRKS 00006075.
水源性瘙痒（AP）是一种未得到充分认识的病症，患者在临床上无皮损的皮肤接触水后会感到瘙痒。AP在患有骨髓增殖性肿瘤（MPN）（如真性红细胞增多症）的患者中很常见，并且可能在MPN诊断前数年就已出现。迄今为止，尚无经过验证的患者报告结局测量指标（PROM）来评估AP及其与MPN的关联。
在这项多阶段研究中，针对77例AP患者和50例慢性非水源性瘙痒（CP）患者，开发并验证了8个与AP相关的问题。在将问题精简为与区分有无MPN的AP相关的问题后，所得问卷在76例AP患者（37例患有MPN）和76例CP患者中进行了验证。该问卷分数的预测能力在第一组中进行了回顾性测试。
确定了四个关键问题，它们是区分AP中MPN的核心，构成了AP问卷（APQ）的基础。该分数的敏感性和特异性分别达到97.3%和79.5%。APQ将5例患有MPN的AP患者分类，这些患者在后期被诊断出患有MPN。
APQ是首个经过验证的针对AP患者的PROM，能以高敏感性检测出与MPN的潜在关系。APQ是对AP患者护理标准的有益补充，可能会缩短MPN诊断的延迟时间。
德国临床试验注册中心，DRKS 00006075。
