Yu Changning, Plaizier Peter, Gong Joshua, Yang Chengbo, Liu Song
Department of Biosystems Engineering, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Department of Animal Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Animals (Basel). 2025 Sep 19;15(18):2739. doi: 10.3390/ani15182739.
Deoxynivalenol (DON) is a mycotoxin produced by and , primarily contaminating wheat, corn, and their derivatives. Although less toxic than some other mycotoxins, DON is significant due to its abundance, particularly in wheat, and its resistance to in vitro detoxification. Compared to other livestock, pigs are the most susceptible animals to DON's presence due to its interaction with wheat-heavy diets. The best way to attenuate the effects of DON is to prevent its presence on cultivated land; however, given that it is difficult to prevent the occurrence of DON in freshly harvested cereals completely, other strategies must be applied. For pigs, chronic consumption of feed with DON concentrations below even the regulated limits can still negatively impact growth. Thus, DON-detoxifying agents including antidotes, DON binding agents, and exogenous in vivo enzyme additives, have been added to feed in an attempt to detoxify DON. This comprehensive review highlights the most recently developed DON-detoxification techniques and assesses each treatment's viability and efficacy, with an emphasis on chemical and biochemical techniques and the rapid development of artificial intelligence (AI) technologies. Herein we explore the unmet needs and future directions of current technologies while discussing promising strategies that can advance the DON-detoxification field.
脱氧雪腐镰刀菌烯醇（DON）是由[具体真菌名称1]和[具体真菌名称2]产生的一种霉菌毒素，主要污染小麦、玉米及其衍生物。尽管DON的毒性比其他一些霉菌毒素小，但由于其含量丰富，尤其是在小麦中，且具有体外解毒抗性，因此它具有重要意义。与其他家畜相比，猪因DON与富含小麦的日粮相互作用，是对DON存在最为敏感的动物。减轻DON影响的最佳方法是防止其在耕地上出现；然而，鉴于很难完全防止新收获谷物中DON的出现，必须采用其他策略。对于猪来说，长期食用DON浓度即使低于规定限量，但仍会对生长产生负面影响。因此，包括解毒剂、DON结合剂和外源性体内酶添加剂在内的DON解毒剂已被添加到饲料中，试图对DON进行解毒。这篇综述重点介绍了最新开发的DON解毒技术，并评估了每种处理方法的可行性和有效性，重点关注化学和生化技术以及人工智能（AI）技术的快速发展。在此，我们探讨了当前技术尚未满足的需求和未来方向，同时讨论了可推动DON解毒领域发展的有前景的策略。
