González-Rodríguez Alexandre, Monreal José Antonio, Natividad Mentxu, Cobo Jesús, Palacios-Hernández Bruma, Susser Leah C
Department of Mental Health, Mutua Terrassa University Hospital, Fundació Docència I Recerca Mutua Terrassa, University of Barcelona (UB), 5 Doctor Robert Square, 08221 Terrassa, Spain.
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 3-5 Calle Monforte de Lemos, Pabellón 11, Planta 0, 28029 Madrid, Spain.
Healthcare (Basel). 2025 Sep 18;13(18):2349. doi: 10.3390/healthcare13182349.
Women with schizophrenia have specific reproductive and fertility care needs that differ from those of men. This narrative review aims to explore the reproductive and fertility care needs of women with schizophrenia related to fertility, menstrual cycle, family planning, and the perinatal period. Hormonal fluctuations in the menstrual cycle can significantly affect clinical symptoms and the efficacy of contraceptive treatments in women with schizophrenia. When undergoing fertility treatment, attention should be given to the potential interactions between fertility treatment drugs and antipsychotics, as well as the potential impact of antipsychotics on the ability to conceive. Although pregnancy rates and participation in fertility programs have increased among women with schizophrenia, very little information is available on the safety and efficacy of fertility treatments in women with severe psychotic disorders. This is an area that warrants further study. Mobilizing social supports and optimizing medication are important components of the treatment of schizophrenia in the perinatal period and are important for the health and safety of infants and mothers. In conclusion, preventing relapse and promoting physical and mental health in this group of women during successive reproductive periods of life is vital and requires an emphasis on the social and psychiatric context, as well as the biological changes occurring at these times.
患有精神分裂症的女性有特定的生殖和生育护理需求，这些需求与男性不同。本叙述性综述旨在探讨患有精神分裂症的女性在生育、月经周期、计划生育和围产期方面的生殖和生育护理需求。月经周期中的激素波动会显著影响精神分裂症女性的临床症状和避孕治疗效果。在接受生育治疗时，应关注生育治疗药物与抗精神病药物之间的潜在相互作用，以及抗精神病药物对受孕能力的潜在影响。尽管精神分裂症女性的怀孕率和参与生育计划的比例有所提高，但关于严重精神障碍女性生育治疗的安全性和有效性的信息却非常少。这是一个值得进一步研究的领域。调动社会支持和优化药物治疗是围产期精神分裂症治疗的重要组成部分，对婴儿和母亲的健康与安全至关重要。总之，在这组女性生命中的连续生殖期预防复发并促进其身心健康至关重要，需要重视社会和精神背景以及此时发生的生物学变化。
