Hegedűs Fanni, Ujfaludi Zsuzsanna, Oláh-Németh Orsolya, Lantos Tamás, Turkevi-Nagy Sándor, Németh István Balázs, Sejben Anita
Department of Pathology, University of Szeged, 6725 Szeged, Hungary.
Competence Centre of the Life Sciences Cluster of the Centre of Excellence for Interdisciplinary Research, Development and Innovation, University of Szeged, 6720 Szeged, Hungary.
Diagnostics (Basel). 2025 Sep 18;15(18):2382. doi: 10.3390/diagnostics15182382.
We hereby present a case of a 51-year-old woman with a pigmented nodule in the right axillary region. Histopathological examination revealed features consistent with an intradermal nevus. Notably, adjacent to the nevus, intralymphatic protrusion and lymphatic invasion were observed, comprising cells with morphological and immunohistochemical characteristics consistent with nevus cells. Next-generation sequencing revealed the mutation. To date, 26 similar cases involving intralymphatic nevus cell protrusion and lymphatic invasion have been reported in the literature. Although this finding is rare and may pose a diagnostic challenge for pathologists, it should not be interpreted as indicative of malignancy. Rather, it must be assessed in the context of the lesion's overall histological architecture.
我们在此报告一例51岁女性，其右腋窝区域有一个色素结节。组织病理学检查显示特征与皮内痣一致。值得注意的是，在痣旁边观察到淋巴管内突出和淋巴管侵犯，包含具有与痣细胞一致的形态学和免疫组化特征的细胞。二代测序揭示了该突变。迄今为止，文献中已报道了26例涉及淋巴管内痣细胞突出和淋巴管侵犯的类似病例。尽管这一发现罕见，可能给病理学家带来诊断挑战，但不应将其解释为恶性的指征。相反，必须结合病变的整体组织学结构进行评估。
