Iacobellis Giulia, Leggio Alessia, Salzillo Cecilia, Imparato Amalia, Marzullo Andrea
Radiology Unit, Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.
Legal Medicine Unit, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.
Cancers (Basel). 2025 Sep 12;17(18):2985. doi: 10.3390/cancers17182985.
Primary Fallopian tube carcinomas (PFTCs) are rare malignancies that are often misclassified as ovarian cancers due to overlapping clinical and pathological features. This frequent misdiagnosis contributes to the under-recognition of PFTCs, which account for a larger proportion of pelvic malignancies than historically reported. The central aim of this literature review is to highlight the critical importance of and methods for achieving an early diagnosis of Fallopian tube cancer, to improve patient outcomes. We classify benign and malignant fallopian tube neoplasms and evaluate the essential role of clinical evaluation and advanced imaging techniques, considering especially ultrasound, MRI, and PET-CT, in achieving an accurate and timely diagnosis. While histopathology remains the gold standard, imaging is pivotal for differentiating benign from malignant tubal lesions. This review details clinical manifestations, diagnostic pitfalls, and the necessity of a multidisciplinary approach to management. We conclude that advancing early detection through refined diagnostic criteria is essential to guiding effective, patient-specific therapeutic interventions.
原发性输卵管癌（PFTC）是一种罕见的恶性肿瘤，由于临床和病理特征重叠，常被误诊为卵巢癌。这种频繁的误诊导致对PFTC的认识不足，与以往报道相比，PFTC在盆腔恶性肿瘤中所占比例更大。这篇文献综述的核心目的是强调早期诊断输卵管癌的至关重要性及方法，以改善患者预后。我们对良性和恶性输卵管肿瘤进行分类，并评估临床评估和先进成像技术（尤其是超声、MRI和PET-CT）在实现准确、及时诊断方面的重要作用。虽然组织病理学仍是金标准，但成像对于区分良性和恶性输卵管病变至关重要。本综述详细阐述了临床表现、诊断陷阱以及多学科管理方法的必要性。我们得出结论，通过完善诊断标准推进早期检测对于指导有效的、针对患者的治疗干预至关重要。
