Marino Giuseppe, Negri Serena, Testa Filippo, Corti Jasmine, Giuliani Daniela, Lugotti Daniele, Grassi Tommaso, Jaconi Marta, Casiraghi Alessandra, Bonazzi Cristina Maria, Fruscio Robert
Obstetrics and Gynecology, Department of Medicine and Surgery, University of Milan-Bicocca, 20126 Milan, Italy.
UO Gynecology, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.
Cancers (Basel). 2025 Sep 18;17(18):3041. doi: 10.3390/cancers17183041.
Immature teratoma of the ovary is a rare condition primarily affecting young women and constitutes a significant proportion of ovarian cancer cases in adolescents and young adults. It is commonly diagnosed at stage I, though advanced-stage disease is not infrequent. Accurate diagnosis and a fertility-sparing approach are central to the management of this condition, as many affected women retain, or have yet to develop, a desire for childbearing. However, due to the rarity of this disease, management is often guided by retrospective data derived from subanalyses of studies on malignant ovarian germ cell tumors, which can complicate the treatment of these patients once diagnosed. The aim of this review is to summarize the current evidence on immature teratoma of the ovary, considering it as a distinct clinical and pathological entity.
卵巢未成熟畸胎瘤是一种主要影响年轻女性的罕见疾病，在青少年和年轻成年人的卵巢癌病例中占相当大的比例。虽然晚期疾病并不少见，但通常在I期被诊断出来。准确的诊断和保留生育功能的方法是这种疾病管理的核心，因为许多受影响的女性仍有生育愿望或尚未有生育愿望。然而，由于这种疾病的罕见性，管理通常以恶性卵巢生殖细胞肿瘤研究的亚分析得出的回顾性数据为指导，这可能会使这些患者一旦被诊断后的治疗变得复杂。本综述的目的是将卵巢未成熟畸胎瘤视为一种独特的临床和病理实体，总结关于它的现有证据。
