Liou Geou-Yarh, Kim Woojung, Hobbs Tamiya M
Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA.
Department of Biological Sciences, Clark Atlanta University, Atlanta, GA 30314, USA.
Antioxidants (Basel). 2025 Aug 28;14(9):1060. doi: 10.3390/antiox14091060.
Prostate cancer is not only the most common type of cancer in elderly American men but also the 2nd leading cause of cancer death in American men. The currently available treatments in clinics target male hormones that are majorly required for maintaining many physiological functions, including muscle strength, leading to poor life quality and subsequent patient-opted intermittent treatment. Aging is a key factor in prostate cancer that is associated with increased levels of oxidative stress. Several lines of evidence indicated elevated levels of reactive oxygen species (ROS) in prostate cancer, including its precursor, prostate intraepithelial neoplasia (PIN). In this current study, we utilized 4-hydroxynonenal (4HNE) as a general readout for overall oxidative stress to demonstrate the imbalance between ROS and antioxidants in human prostate cancer and its precursor lesion in both human culture cell lines and tissue samples. Our results showed that the production of 4HNE adducts was increased in human prostate cancer cells and was non-linearly correlated with prostate cancer stage. They also provided insight into prevention and potential therapeutic strategies for prostate cancer.
前列腺癌不仅是美国老年男性中最常见的癌症类型，也是美国男性癌症死亡的第二大主要原因。目前临床上可用的治疗方法针对的是维持包括肌肉力量在内的许多生理功能所主要需要的雄性激素，这导致生活质量较差，随后患者选择间歇性治疗。衰老在前列腺癌中是一个关键因素，与氧化应激水平升高有关。多项证据表明前列腺癌中活性氧（ROS）水平升高，包括其前体前列腺上皮内瘤变（PIN）。在本研究中，我们使用4-羟基壬烯醛（4HNE）作为整体氧化应激的一般指标，以证明人前列腺癌及其前体病变在人培养细胞系和组织样本中ROS与抗氧化剂之间的失衡。我们的结果表明，4HNE加合物在人前列腺癌细胞中的产生增加，并且与前列腺癌分期呈非线性相关。它们还为前列腺癌的预防和潜在治疗策略提供了见解。
