Czubak Paweł, Herda Karolina, Niewiadomska Iwona, Putowski Lechosław, Łańcut Mirosław, Masłyk Maciej
Department of Molecular Biology, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland.
Department of Biomedical and Analytical Chemistry, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland.
Int J Mol Sci. 2025 Sep 12;26(18):8878. doi: 10.3390/ijms26188878.
Endometriosis is a complex gynecological condition affecting 10% of women globally, characterized by the growth of endometrial-like tissue outside the uterus, leading to chronic pelvic pain, infertility, reduced quality of life, and a risk of cancer. This review examines the multifaceted aspects of endometriosis, including its causes, diagnostic approaches, and management strategies. Genetic and environmental factors, hormonal influences, and immunological dysregulation are addressed as potential drivers of disease progression. Treatment options, including pharmacological interventions (hormone therapy, pain management) and surgical interventions, are assessed for their effectiveness in alleviating symptoms and improving outcomes. Emerging therapies, such as small-molecule inhibitors and anti-angiogenic agents, are also explored. Additionally, the psychological impact of endometriosis is addressed, emphasizing the need for holistic care. This review highlights the importance of continued research to unravel the precise mechanisms underlying endometriosis and to develop targeted therapies for improved patient care.
子宫内膜异位症是一种复杂的妇科疾病,全球10%的女性受其影响,其特征是子宫外出现类似子宫内膜的组织生长,导致慢性盆腔疼痛、不孕、生活质量下降以及患癌风险。本综述探讨了子宫内膜异位症的多方面问题,包括其病因、诊断方法和管理策略。遗传和环境因素、激素影响以及免疫失调被视为疾病进展的潜在驱动因素。评估了包括药物干预(激素治疗、疼痛管理)和手术干预在内的治疗选择在缓解症状和改善预后方面的有效性。还探索了新兴疗法,如小分子抑制剂和抗血管生成剂。此外,还讨论了子宫内膜异位症的心理影响,强调了整体护理的必要性。本综述强调了持续研究以阐明子宫内膜异位症的确切机制并开发针对性疗法以改善患者护理的重要性。