D'Agati Giulio, Mignone Lorena, Bartolone Antonella, Sciortino Giuseppa, Fasciana Teresa Maria Assunta, Calà Cinzia, Bonura Silvia, Carini Francesco, Pipitò Luca, Cascio Antonio
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G D'Alessandro", University of Palermo, 90127 Palermo, Italy.
Infectious and Tropical Disease Unit, AOU Policlinico "P. Giaccone", 90127 Palermo, Italy.
Antibiotics (Basel). 2025 Aug 24;14(9):854. doi: 10.3390/antibiotics14090854.
BACKGROUND/OBJECTIVES: species are Gram-negative, non-motile, non-fermentative, obligate anaerobic cocci. They are typically considered commensals of the oral cavity, respiratory tract, genitourinary tract, and gastrointestinal tract. It may be a rare cause of dental infections and discitis/spondylodiscitis.
We report the case of an 80-year-old patient diagnosed with discitis caused by , isolated from blood. In addition, we performed a comprehensive literature review summarizing all reported cases of discitis or spondylodiscitis caused by species.
In our case, antimicrobial susceptibility testing was performed using the Kirby-Bauer disc diffusion method. Based on the results, the patient was treated with amoxicillin/clavulanate, which led to a favourable clinical outcome. A review of the literature revealed that, to date, only 14 cases of spondylodiscitis or discitis caused by spp. have been reported. Potential risk factors for spp. bacteremia were identified in only 9 cases. The most commonly affected site was the lumbar or lumbosacral spine. Magnetic resonance imaging was consistently regarded as the diagnostic gold standard. Most patients presented with localized pain. The overall therapeutic approach generally consisted of an initial course of intravenous antibiotics, typically ceftriaxone administered either as monotherapy or in combination with metronidazole, followed by an oral regimen with amoxicillin/clavulanate, given alone or alongside metronidazole.
Spondylodiscitis due to remains extremely rare. Although antimicrobial susceptibility patterns remain heterogeneous, beta-lactams, particularly amoxicillin/clavulanate, appear effective in most cases, and treatment regimens typically involve an initial intravenous phase followed by oral therapy.
背景/目的：[具体菌种]为革兰氏阴性、无动力、不发酵、专性厌氧球菌。它们通常被认为是口腔、呼吸道、泌尿生殖道和胃肠道的共生菌。它可能是牙科感染和椎间盘炎/脊椎椎间盘炎的罕见病因。
我们报告了一例80岁患者的病例，该患者被诊断为由从血液中分离出的[具体菌种]引起的椎间盘炎。此外，我们进行了全面的文献综述，总结了所有报道的由[具体菌种]引起的椎间盘炎或脊椎椎间盘炎病例。
在我们的病例中，使用 Kirby-Bauer 纸片扩散法进行了药敏试验。根据结果，患者接受阿莫西林/克拉维酸治疗，临床结果良好。文献综述显示，迄今为止，仅报道了14例由[具体菌种]引起的脊椎椎间盘炎或椎间盘炎病例。仅在9例病例中确定了[具体菌种]菌血症的潜在危险因素。最常受累的部位是腰椎或腰骶椎。磁共振成像一直被视为诊断金标准。大多数患者表现为局部疼痛。总体治疗方法通常包括初始静脉抗生素疗程，通常使用头孢曲松单药治疗或与甲硝唑联合使用，随后口服阿莫西林/克拉维酸，单独使用或与甲硝唑一起使用。
由[具体菌种]引起的脊椎椎间盘炎仍然极为罕见。尽管药敏模式仍然存在异质性，但β-内酰胺类药物，特别是阿莫西林/克拉维酸，在大多数情况下似乎有效，治疗方案通常包括初始静脉治疗阶段，随后是口服治疗。
