Zmork-Martínez Gerardo Ricardo, Higuera-Ruiz-de-la-Hermosa Andrea, Portocarrero-Sánchez Leonardo, Díaz-de-Terán Javier
Department of Neurology, La Paz University Hospital and Stroke Center, 28046 Madrid, Spain.
Hospital La Paz Institute for Health Research-IdiPAZ, La Paz University Hospital, Universidad Autónoma de Madrid, 28046 Madrid, Spain.
J Clin Med. 2025 Sep 14;14(18):6475. doi: 10.3390/jcm14186475.
: Personality traits in patients with cluster headache (CH) remain understudied compared to migraine patients. This could help improve diagnosis, identify comorbidities, and provide more personalized management of CH. This study aimed to characterize the personality profiles of patients with CH and compare them with those of patients with migraine. : This cross-sectional, case-control observational study was conducted at a tertiary hospital's headache unit (May-August 2024). Patients with CH were compared with migraine patients and healthy controls. Demographic and clinical data were collected, and the Minnesota Multiphasic Personality Inventory-3 (MMPI-3) was administered. : The study included 28 CH patients (17 with episodic and 11 with chronic CH), 55 migraine patients (34 with episodic migraine and 21 with chronic migraine), and 54 healthy controls. Both patient groups reported significantly more somatic and cognitive complaints than controls ( < 0.05). Compared to controls, the migraine group exhibited greater emotional dysfunction, social avoidance, demoralization, introversion, and social anxiety ( < 0.05), while the CH group showed greater impulsivity ( < 0.05). Directly comparing patient groups, migraine patients displayed greater social avoidance, emotional dysfunction, demoralization, and introversion than the CH group ( < 0.05). CH patients also showed a non-significant trend towards behavioral disinhibition, hypomania, a favorable self-image, juvenile conduct problems, substance abuse, and aggressiveness. Patients with CH did not present a higher risk of suicide compared to migraine patients. : This study identified distinct personality profiles: Migraine patients exhibited greater emotional and interpersonal dysfunction (internal distress and withdrawal), while CH patients exhibited greater externalizing behavioral dysfunction, predominantly involving impulsivity.
与偏头痛患者相比，丛集性头痛（CH）患者的人格特质仍未得到充分研究。这有助于改善CH的诊断、识别合并症并提供更个性化的管理。本研究旨在描述CH患者的人格特征，并将其与偏头痛患者的人格特征进行比较。：这项横断面、病例对照观察性研究于一家三级医院的头痛科进行（2024年5月至8月）。将CH患者与偏头痛患者和健康对照进行比较。收集了人口统计学和临床数据，并进行了明尼苏达多相人格问卷-3（MMPI-3）测试。：该研究纳入了28例CH患者（17例发作性CH和11例慢性CH）、55例偏头痛患者（34例发作性偏头痛和21例慢性偏头痛）和54例健康对照。两组患者报告的躯体和认知主诉均明显多于对照组（<0.05）。与对照组相比，偏头痛组表现出更大的情绪功能障碍、社交回避、士气低落、内向和社交焦虑（<0.05），而CH组表现出更大的冲动性（<0.05）。直接比较患者组，偏头痛患者比CH组表现出更大的社交回避、情绪功能障碍、士气低落和内向（<0.05）。CH患者在行为抑制、轻躁狂、良好的自我形象、青少年行为问题、药物滥用和攻击性方面也呈现出不显著的趋势。与偏头痛患者相比，CH患者没有更高的自杀风险。：本研究确定了不同的人格特征：偏头痛患者表现出更大的情绪和人际功能障碍（内心痛苦和退缩），而CH患者表现出更大的外化行为功能障碍，主要涉及冲动性。
