Mantle David, Cufflin Neve, Purcell Tyler T, Hargreaves Iain P
Pharma Nord (UK) Ltd., Morpeth NE61 2DB, UK.
School of Pharmacy, Liverpool John Moores University, Liverpool L3 5UA, UK.
J Clin Med. 2025 Sep 15;14(18):6486. doi: 10.3390/jcm14186486.
The success of organ transplantation can be compromised by ischaemia-reperfusion injury (IRI), an unavoidable consequence of transplant surgery. IRI is associated with mitochondrial dysfunction, oxidative stress, inflammation, and apoptosis/ferroptosis. There is therefore a rationale for supplementation with coenzyme Q10 (CoQ10) to mediate the adverse effects of IRI, given the role of CoQ10 in promoting normal mitochondrial function, as an antioxidant, and as an anti-inflammatory and anti-apoptotic/ferroptotic agent. In this article we have reviewed the potential role of supplementary CoQ10 in organ transplantation in preclinical animal studies based on the above actions; the role of supplementary CoQ10 in promoting stem cell action in transplantation and its role in alleviating the adverse effects of immunosuppressants used in organ transplantation are also discussed.
缺血再灌注损伤（IRI）是移植手术不可避免的后果，会影响器官移植的成功率。IRI与线粒体功能障碍、氧化应激、炎症以及细胞凋亡/铁死亡有关。鉴于辅酶Q10（CoQ10）在促进正常线粒体功能、作为抗氧化剂以及作为抗炎和抗凋亡/抗铁死亡剂方面的作用，补充CoQ10以介导IRI的不良影响是有理论依据的。在本文中，我们基于上述作用，综述了补充CoQ10在临床前动物研究中对器官移植的潜在作用；还讨论了补充CoQ10在促进移植中干细胞作用方面的作用及其在减轻器官移植中使用的免疫抑制剂不良反应方面的作用。
