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压力性尿失禁女性经尿道应用Bulkamid成功的尿道活动度预测性测量

Predictive Measurement of Urethral Mobility for Successful Transurethral Bulkamid Application in Women with Stress Urinary Incontinence.

作者信息

Nosal Norbert, Gerling Andrea, Kuhn Annette, Pfleiderer Mathieu, Baek Sunhwa, Ludwig Sebastian

机构信息

Gynecology and Obstetrics, Elisabeth Hospital Essen, 45138 Essen, Germany.

Division of Uorgynecology, Inselspital Bern, Women's Hospital, Switzerland and University of Bern, 3010 Bern, Switzerland.

出版信息

J Clin Med. 2025 Sep 18;14(18):6555. doi: 10.3390/jcm14186555.

DOI:10.3390/jcm14186555
PMID:41010759
Abstract

: Bulking agents such as Bulkamid are well-established surgical options for the treatment of stress urinary incontinence (SUI). Pelvic floor sonographic imaging is readily accessible and may assist in identifying patients who are more likely to benefit from bulking therapies. Urethral mobility appears to significantly influence treatment outcomes and can be classified into hypo-, normo-, and hypermobility. The primary aim of this study was to evaluate the impact of sonographic urethral mobility on the success rate of Bulkamid injections. The secondary objective was to assess differences between pre- and postoperative urinary incontinence scores. : In women with SUI, linear dorsocaudal movement (LDM) of the urethra was measured sonographically. The International Consultation on Incontinence Modular Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) was completed prior to Bulkamid injection. Patients were categorized into hypo-, normo-, and hypermobility groups based on their LDM measurements. : A total of 130 patients participated, with 101 undergoing both pre- and postoperative sonographic assessment. The difference in LDM before and after treatment was calculated. Patients with normomobile urethras (n = 79) exhibited the greatest mean improvement in continence scores, with LDM changes ranging from 6 to 24 mm and an average ICIQ-UI SF score reduction of 3.8 points. Patients with hypomobile (n = 16) or hypermobile urethras (n = 6) also demonstrated improvements, but to a lesser extent than the normomobile group. : This study indicates that patients with a normomobile urethra experience the most significant improvement in continence outcomes following Bulkamid injection. Urethral mobility assessment via sonography may serve as a valuable preoperative tool and appears to play a crucial role in predicting treatment success with bulking agents.

摘要

诸如Bulkamid之类的填充剂是治疗压力性尿失禁(SUI)的成熟手术选择。盆底超声成像易于获取,可帮助识别更可能从填充治疗中获益的患者。尿道活动度似乎对治疗结果有显著影响,可分为活动度降低、正常和活动度增加。本研究的主要目的是评估超声检查的尿道活动度对Bulkamid注射成功率的影响。次要目的是评估术前和术后尿失禁评分的差异。

在患有SUI的女性中,通过超声测量尿道的线性背尾向移动(LDM)。在注射Bulkamid之前完成国际尿失禁咨询模块化问卷-尿失禁简表(ICIQ-UI SF)。根据LDM测量结果,将患者分为活动度降低、正常和活动度增加组。

共有130名患者参与,其中101名接受了术前和术后超声评估。计算治疗前后LDM的差异。尿道活动度正常的患者(n = 79)在控尿评分方面平均改善最大,LDM变化范围为6至24毫米,ICIQ-UI SF评分平均降低3.8分。尿道活动度降低(n = 16)或活动度增加(n = 6)的患者也有改善,但程度小于尿道活动度正常组。

本研究表明,尿道活动度正常的患者在注射Bulkamid后控尿结果改善最为显著。通过超声评估尿道活动度可作为一种有价值的术前工具,似乎在预测填充剂治疗成功方面起着关键作用。

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