Sánchez-Barrera Cuauhtémoc Ángel, Fernandez-Muñoz Karen V, Mendoza-Rodríguez Mónica G, Ortiz-Melo María T, Carrillo-Pérez Jazmín A, Rodríguez-Sosa Miriam, Terrazas Luis I
Unidad de Investigación en Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Avenida de los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico.
Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, Ciudad de México 07360, Mexico.
Pathogens. 2025 Sep 20;14(9):949. doi: 10.3390/pathogens14090949.
Worldwide, colorectal cancer (CRC) is the third-most common cancer and the second-leading cause of cancer-related deaths. The inflammatory response initiated by pathogens, environmental and dietary factors, and inflammatory bowel diseases can promote the formation of colorectal tumors. The hygiene hypothesis proposes an inverse link between inflammatory diseases and early childhood exposure to pathogens, with a significant negative correlation between chronic inflammatory diseases and helminth infections. On the other hand, it is also known that several pathogens may influence or even cause the development of cancer, including helminth infections. How do helminth infections influence CRC outcomes? The existing literature presents two different perspectives. Experimental studies in CRC models suggest that helminths may accelerate disease progression and lead to worse outcomes (such as and sp.), while others indicate that helminths could help reduce tumor burden (such as sp.). This review focuses on helminths' pro- and anti-tumorigenic effects and their derivatives, specifically in CRC. We provide a comprehensive understanding of how helminths impact the macroscopic, histopathological, immunological, and molecular aspects of CRC.
在全球范围内，结直肠癌（CRC）是第三大常见癌症，也是癌症相关死亡的第二大主要原因。由病原体、环境和饮食因素以及炎症性肠病引发的炎症反应可促进结直肠肿瘤的形成。卫生假说提出炎症性疾病与儿童早期接触病原体之间存在反比关系，慢性炎症性疾病与蠕虫感染之间存在显著的负相关。另一方面，也已知几种病原体可能影响甚至导致癌症的发展，包括蠕虫感染。蠕虫感染如何影响结直肠癌的预后？现有文献呈现出两种不同的观点。在结直肠癌模型中的实验研究表明，蠕虫可能加速疾病进展并导致更差的预后（如 和 属），而其他研究则表明蠕虫有助于减轻肿瘤负担（如 属）。本综述重点关注蠕虫的促肿瘤和抗肿瘤作用及其衍生物，特别是在结直肠癌方面。我们全面了解了蠕虫如何影响结直肠癌的宏观、组织病理学、免疫学和分子方面。
