Saadeldein Mohamed Soud, Gismalla Mohamed Daffalla Awadalla, Alnkhly Mustafa Yousif Altahir
Department of Surgery, Faculty of Medicine, University of Gezira, Medani, Sudan.
Department of Surgery, Faculty of Medicine, Al Baha University, Al Baha, Saudi Arabia.
J Med Case Rep. 2025 Sep 26;19(1):451. doi: 10.1186/s13256-025-05443-4.
Eumycetoma is an endemic chronic granulomatous infection in tropical and subtropical regions, including Sudan.
This case series presents three Sudanese patients with intracranial mycetoma (27-year-old female from Central Sudan, 20-year-old male from Central Sudan, and 23-year-old male from West Sudan), highlighting different clinical presentations, diagnostic challenges, and management strategies. All cases involved young individuals with painless swellings, discharging sinuses, and other central nervous system manifestations. The diagnosis was confirmed by different histopathological and imaging modalities. Surgical management was performed for the localized lesion case but, unfortunately, the other two cases were difficult to operate on owing to the large extension of the disease and were followed with medical management.
This series highlights the difficulties in diagnosing and managing cases of intracranial mycetoma. It emphasizes the importance of early diagnosis, multidisciplinary management, and public health efforts to reduce the burden of mycetoma in endemic regions.
足菌肿是一种在包括苏丹在内的热带和亚热带地区流行的慢性肉芽肿性感染。
本病例系列介绍了三名患有颅内足菌肿的苏丹患者（一名来自苏丹中部的27岁女性、一名来自苏丹中部的20岁男性和一名来自苏丹西部的23岁男性），突出了不同的临床表现、诊断挑战和管理策略。所有病例均涉及年轻个体，有无痛性肿胀、排脓窦道及其他中枢神经系统表现。通过不同的组织病理学和影像学检查手段确诊。对局限性病变病例进行了手术治疗，但遗憾的是，另外两例因疾病广泛扩散难以进行手术，采用药物治疗进行随访。
本系列突出了颅内足菌肿病例诊断和管理的困难。强调了早期诊断、多学科管理以及公共卫生努力在减轻流行地区足菌肿负担方面的重要性。
