Yang Bei, Liu Jie
School of Basic Medical Sciences, Nanchang University, Nanchang, China.
Basic Clin Pharmacol Toxicol. 2025 Nov;137(5):e70117. doi: 10.1111/bcpt.70117.
As a replacement for phased-out perfluorooctanoic acid (PFOA), hexafluoropropylene oxide trimer carboxylic acid (HFPO-TA) exhibits environmental persistence and multisystem toxicity, affecting reproductive, hepatic, neurological and endocrine functions. Despite its industrial adoption, emerging studies reveal bioaccumulation risks and mechanistic toxicity through oxidative stress, metabolic disruption and inflammation. This review synthesizes evidence of HFPO-TA's health impacts, highlighting unresolved female reproductive toxicity and dose-response relationships.
作为逐步淘汰的全氟辛酸（PFOA）的替代品，六氟环氧丙烷三聚体羧酸（HFPO-TA）具有环境持久性和多系统毒性，会影响生殖、肝脏、神经和内分泌功能。尽管它已在工业中得到应用，但新出现的研究揭示了其生物累积风险以及通过氧化应激、代谢紊乱和炎症产生的机制毒性。本综述综合了关于HFPO-TA对健康影响的证据，突出了尚未解决的女性生殖毒性和剂量反应关系。
