Howe M L, Battisto J R
Immunology. 1971 Mar;20(3):407-13.
The delayed-type iso-hypersensitivity that guinea-pigs acquire spontaneously towards a β-globulin antigen of other guinea-pigs has been measured . Serum containing the antigen specifically triggers lymphocytes from naturally iso-hypersensitive animals to undergo blastogenic response. This reaction is similar to that of lymphocytes cultured in the presence of antigen to which cell donors have been intentionally immunized. Thus, the technique of DNA synthesis may be used to detect both artificially induced and naturally occurring delayed-type hypersensitivities. In addition, naturally existing delayed hypersensitivity offers a plausible explanation for reports of spontaneous transformation of lymphocytes by homologous or heterologous serum and of certain other phenomena involving interaction of lymphoid cells from non-immunized donors.
豚鼠对其他豚鼠的β-球蛋白抗原自发获得的迟发型同种超敏反应已被检测。含有该抗原的血清能特异性地触发来自天然同种超敏动物的淋巴细胞发生增殖反应。这种反应类似于在细胞供体已被有意免疫的抗原存在下培养的淋巴细胞的反应。因此，DNA合成技术可用于检测人工诱导的和天然存在的迟发型超敏反应。此外，天然存在的迟发型超敏反应为关于同源或异源血清导致淋巴细胞自发转化以及涉及未免疫供体淋巴细胞相互作用的某些其他现象的报道提供了合理的解释。
