Konuk Suat, Ozel Alp, Ozsari Emine, Nasircilar Askin
Department of Chest Diseases, Bolu Abant Izzet Baysal University, Bolu, Turkey.
Department of Physiotherapy and Rehabilitation, Bolu Abant Izzet Baysal University, Bolu, Turkey.
Ann Med. 2025 Dec;57(1):2566392. doi: 10.1080/07853890.2025.2566392. Epub 2025 Sep 29.
Asthma and fibromyalgia are chronic conditions that significantly impair quality of life and share common inflammatory and neurophysiological mechanisms.
This study aimed to investigate the prevalence of fibromyalgia in asthma patients and examine its impact on asthma control.
In this case-control study, 120 patients diagnosed with asthma and 120 age- and sex-matched healthy controls were enrolled. Fibromyalgia was diagnosed based on the 2016 revised ACR criteria using the Widespread Pain Index (WPI) and Symptom Severity Scale (SSS). Asthma control was assessed using the Asthma Control Test (ACT). The relationship between fibromyalgia and asthma control was analyzed using independent t-tests, chi-square tests, logistic regression, and ROC analysis.
The prevalence of fibromyalgia in the asthma group was 16.7% compared to 3.3% in controls ( < 0.001). Asthma patients with fibromyalgia had significantly lower ACT scores than those without (18.2 ± 2.9 vs. 20.1 ± 2.4; = 0.004). The proportion of patients with uncontrolled asthma was higher among those with fibromyalgia (60% vs. 35%). Logistic regression showed that fibromyalgia was associated with increased odds of uncontrolled asthma (OR = 2.16), although this was not statistically significant ( = 0.103). ACT scores showed no significant correlation with WPI or SSS. ROC analysis revealed that the ACT score had no discriminatory power in identifying fibromyalgia (AUC = 0.50).
Fibromyalgia is a common comorbidity in asthma patients and may adversely affect perceived asthma control. However, the ACT score alone may not be a reliable indicator of fibromyalgia presence, suggesting the need for multidimensional assessment tools in routine asthma care.
哮喘和纤维肌痛是严重影响生活质量的慢性疾病，且具有共同的炎症和神经生理机制。
本研究旨在调查哮喘患者中纤维肌痛的患病率，并探讨其对哮喘控制的影响。
在这项病例对照研究中，纳入了120例诊断为哮喘的患者和120例年龄及性别匹配的健康对照。根据2016年修订的美国风湿病学会（ACR）标准，使用广泛性疼痛指数（WPI）和症状严重程度量表（SSS）诊断纤维肌痛。使用哮喘控制测试（ACT）评估哮喘控制情况。采用独立t检验、卡方检验、逻辑回归和ROC分析来分析纤维肌痛与哮喘控制之间的关系。
哮喘组中纤维肌痛的患病率为16.7%，而对照组为3.3%（P<0.001）。患有纤维肌痛的哮喘患者的ACT评分显著低于未患纤维肌痛的患者（18.2±2.9 vs. 20.1±2.4；P = 0.004）。在患有纤维肌痛的患者中，哮喘未得到控制的患者比例更高（60% vs. 35%）。逻辑回归显示，纤维肌痛与哮喘未得到控制的几率增加相关（OR = 2.16），尽管这在统计学上无显著意义（P = 0.103）。ACT评分与WPI或SSS无显著相关性。ROC分析显示，ACT评分在识别纤维肌痛方面没有鉴别能力（AUC = 0.50）。
纤维肌痛是哮喘患者中常见的合并症，可能对哮喘控制的自我感觉产生不利影响。然而，仅ACT评分可能不是纤维肌痛存在的可靠指标，这表明在常规哮喘护理中需要多维评估工具。
