Lei Jun, Liu Yong, Yuan Shuai, Yuan Xiaxia, Yuan Qi
Department of State-owned Assets Management, Mudanjiang Medical University, Mudanjiang, China.
Center for Comparative Medicine, Mudanjiang Medical University, Mudanjiang, China.
Front Cell Dev Biol. 2025 Sep 12;13:1520739. doi: 10.3389/fcell.2025.1520739. eCollection 2025.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide and the most common primary tumor. Periostin (POSTN) is located in the extracellular matrix (ECM) and triggers tumor growth signals by binding to integrin receptors. The interaction of highly expressed POSTN with cell surface receptor integrins regulates intracellular signaling pathways and promotes HCC progression. In this review, the structure and isoforms of POSTN will be summarized, and the relationship between POSTN-integrin signaling and the diagnosis and prognosis of HCC patients, tumor cell proliferation and metastasis, immune escape, cancer stem cells and angiogenesis will be reviewed. The interaction between POSTN-integrin and the key signaling pathways of HCC and its mechanism in disease progression were emphasized, and the potential value of this signaling axis as a therapeutic target for HCC was explored, providing a theoretical basis for in-depth understanding of the pathophysiological process of HCC and the development of new therapeutic strategies.
肝细胞癌（HCC）是全球癌症死亡的第三大主要原因，也是最常见的原发性肿瘤。骨膜蛋白（POSTN）位于细胞外基质（ECM）中，通过与整合素受体结合触发肿瘤生长信号。高表达的POSTN与细胞表面受体整合素的相互作用调节细胞内信号通路并促进HCC进展。在本综述中，将总结POSTN的结构和异构体，并综述POSTN-整合素信号与HCC患者的诊断和预后、肿瘤细胞增殖和转移、免疫逃逸、癌症干细胞和血管生成之间的关系。强调了POSTN-整合素与HCC关键信号通路之间的相互作用及其在疾病进展中的机制，并探讨了该信号轴作为HCC治疗靶点的潜在价值，为深入理解HCC的病理生理过程和开发新的治疗策略提供理论依据。
