Castaño Cardozo Michel S, Valderrama Teran Claudia Valentina, Valderrama Teran Alejandro, Valderrama Cometa Luis Alfonso
Department of Nephrology, Centro Médico Imbanaco, Cali, COL.
Department of Medicine, Instituto Colombiano de Estudios Superiores de Incolda (ICESI) University, Cali, COL.
Cureus. 2025 Aug 27;17(8):e91109. doi: 10.7759/cureus.91109. eCollection 2025 Aug.
Deep vein thrombosis (DVT) is a common venous thrombotic disorder. Current treatment strategies focus on anticoagulation and pharmacomechanical thrombectomy technologies; however, associated complications must be considered. Acute kidney injury (AKI) secondary to hemoglobinuria requiring renal replacement therapy is a rare yet serious complication of mechanical thrombectomy with the AngioJet® rheolytic thrombectomy system. This report describes the case of a 47-year-old male patient who developed AKI, hemoglobinuria, and metabolic acidosis within hours of the procedure. Despite fluid administration and urine alkalinization, renal replacement therapy was required; renal function subsequently recovered. This case illustrates the risk of AKI from hemoglobinuria associated with mechanical thrombectomy, plausibly mediated by hemolysis and oxidative stress leading to renal tubular obstruction. Close renal monitoring and individualized risk‑factor assessment facilitate early recognition and timely intervention, potentially mitigating the risk of chronic kidney disease.
深静脉血栓形成（DVT）是一种常见的静脉血栓性疾病。目前的治疗策略侧重于抗凝和药物机械性血栓切除术技术；然而，必须考虑相关并发症。继发于血红蛋白尿且需要肾脏替代治疗的急性肾损伤（AKI）是使用AngioJet® 流变血栓切除术系统进行机械性血栓切除术的一种罕见但严重的并发症。本报告描述了一名47岁男性患者的病例，该患者在手术后数小时内出现了AKI、血红蛋白尿和代谢性酸中毒。尽管进行了补液和尿液碱化治疗，但仍需要肾脏替代治疗；随后肾功能恢复。该病例说明了与机械性血栓切除术相关的血红蛋白尿导致AKI的风险，可能是由溶血和氧化应激介导，进而导致肾小管梗阻。密切的肾脏监测和个体化的风险因素评估有助于早期识别和及时干预，有可能降低慢性肾脏病的风险。
