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急性痘疮样苔藓样糠疹的罕见表现：一名15岁男性黏膜和面部受累病例

Rare Presentation of Pityriasis Lichenoides et Varioliformis Acuta: A Case of Mucosal and Face Involvement in a 15-Year-Old Male.

作者信息

Shah Sandesh, Shrestha Joshana, Piya Smriti

机构信息

Department of Dermatology Nepal Medical College and Teaching Hospital Kathmandu Nepal.

出版信息

Clin Case Rep. 2025 Sep 26;13(10):e71010. doi: 10.1002/ccr3.71010. eCollection 2025 Oct.

DOI:10.1002/ccr3.71010
PMID:41018980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12474653/
Abstract

Pityriasis lichenoides et varioliformis acuta (PLEVA) is a rare inflammatory skin disorder, and mucosal involvement is exceptionally uncommon. We present a 15-year-old male who developed PLEVA with facial and mucosal involvement, preceded by fever. Dermoscopy revealed dotted and linear vessels with micaceous scales. Histopathology showed focal parakeratosis, epidermal exocytosis of neutrophils and lymphocytes, and dense inflammatory infiltrates extending into the subcutaneous tissue. The patient responded well to doxycycline, achieving complete resolution, though varioliform scarring and hyperpigmentation remained. This case underscores the rarity of mucosal involvement in PLEVA and highlights the importance of early recognition and treatment to minimize long-term cutaneous damage.

摘要

急性痘疮样苔藓状糠疹（PLEVA）是一种罕见的炎症性皮肤病，累及黏膜的情况极为罕见。我们报告一名15岁男性，他在发热后出现了累及面部和黏膜的PLEVA。皮肤镜检查显示有散在点状和线状血管及云母状鳞屑。组织病理学显示灶性角化不全、中性粒细胞和淋巴细胞的表皮内渗以及延伸至皮下组织的致密炎症浸润。患者对强力霉素反应良好，实现了完全缓解，不过仍留下了痘疮样瘢痕和色素沉着。该病例强调了PLEVA累及黏膜的罕见性，并突出了早期识别和治疗对于将长期皮肤损害降至最低的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/cd401e471344/CCR3-13-e71010-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/007ba3173b6d/CCR3-13-e71010-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/e6bd19730cfa/CCR3-13-e71010-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/3cf58dbaf948/CCR3-13-e71010-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/5c8c00950b99/CCR3-13-e71010-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/1008a4c1a86d/CCR3-13-e71010-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/6ed7a62ff77a/CCR3-13-e71010-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/df21d02c45ac/CCR3-13-e71010-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/cd401e471344/CCR3-13-e71010-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/007ba3173b6d/CCR3-13-e71010-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/e6bd19730cfa/CCR3-13-e71010-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/3cf58dbaf948/CCR3-13-e71010-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/5c8c00950b99/CCR3-13-e71010-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/1008a4c1a86d/CCR3-13-e71010-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/6ed7a62ff77a/CCR3-13-e71010-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/df21d02c45ac/CCR3-13-e71010-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/799e/12474653/cd401e471344/CCR3-13-e71010-g003.jpg

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本文引用的文献

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Pityriasis lichenoides et varioliformis acuta following measles rubella vaccine.麻疹风疹疫苗接种后急性痘疮样苔藓状糠疹
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An Atypical Presentation of PLEVA: Case Report and Review of the Literature.点滴状副银屑病的非典型表现：病例报告及文献综述
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