Morawiec Maria-Laura, Kubina Robert, Jabłońska Ewa, Ratajczak-Wrona Wioletta, Stępień Sebastian, Gołębski Maciej, Mielczarek-Palacz Aleksandra
Department of Immunology and Serology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Katowice, Poland.
Silesia LabMed: Centre for Research and Implementation, Medical University of Silesia in Katowice, Katowice, Poland.
Front Immunol. 2025 Sep 12;16:1666261. doi: 10.3389/fimmu.2025.1666261. eCollection 2025.
NETs are network-like structures consisting mainly of DNA and various proteins released by neutrophils physiologically in response to pathogens. Moreover, according to recent reports, NETs also play an important role in carcinogenesis. They are involved in all stages of carcinogenesis, assist in the process of metastasis, and their presence has been linked to higher mortality and poorer prognosis in numerous cancer types. This review focuses on anti-cancer treatments related to disintegration of existing NETs, inhibition of their formation and regulation of their formation. Cases in which the presence of NETs was associated with anti-cancer activity and the association of NETs with complications co-occurring with cancer or related to cancer treatment was presented. This paper also presents mechanisms of NETs inhibition, predicting the efficacy or resistance of anti-cancer therapy associated with NETs.
中性粒细胞胞外陷阱（NETs）是一种网络状结构，主要由中性粒细胞在生理状态下响应病原体时释放的DNA和各种蛋白质组成。此外，根据最近的报道，NETs在致癌过程中也起着重要作用。它们参与致癌的各个阶段，协助转移过程，并且它们的存在与多种癌症类型的更高死亡率和更差预后相关。本综述聚焦于与现有NETs解体、抑制其形成以及调控其形成相关的抗癌治疗。文中介绍了NETs的存在与抗癌活性相关的案例，以及NETs与癌症并发或与癌症治疗相关的并发症之间的关联。本文还阐述了NETs的抑制机制，预测了与NETs相关的抗癌治疗的疗效或耐药性。
