Liu Yvonne, Hocher Johann-Georg, Ma Shujuan, Hu Liang, Chen Huijun, Zhang Xiaoli, Gong Fei, Krämer Bernhard K, Lin Ge, Hocher Berthold
Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.
Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China.
Front Endocrinol (Lausanne). 2025 Sep 11;16:1647131. doi: 10.3389/fendo.2025.1647131. eCollection 2025.
With ongoing global lifestyle changes and economic development, the prevalence of hyperuricemia has steadily increased. Elevated levels of serum uric acid (SUA) have been linked to gestational diabetes mellitus (GDM); however, this relationship has not yet been specifically evaluated in women undergoing assisted reproductive technology (ART). Therefore, this study aimed to analyze the relationship between pre-pregnancy SUA as well as SUA to serum creatinine (SCr) ratio and GDM in women undergoing ART.
This retrospective cohort study was carried out at the Reproductive and Genetic Hospital of CITIC-Xiangya in Changsha, Hunan, China, and included 1027 women who underwent their first ART treatment between 2017 and 2018. SUA levels were measured during the baseline visit prior to any ART procedures, and GDM incidence was recorded based on screening results from the oral glucose tolerance test.
GDM was diagnosed in 172 (16.7%) of the 1027 patients. When comparing SUA quintiles, significant differences were observed in GDM incidence, and several other parameters (including pre-pregnancy weight, BMI, blood glucose, blood pressure, SCr, lipid parameters, anti-Müllarian Hormone, follicle stimulating hormone, and testosterone). SUA was independently associated with GDM incidence after adjusting for potential confounding factors in multivariate analysis (OR 1.004, = 0.003). Moreover, the SUA/SCr ratio displayed an even stronger association (OR 1.226, = 0.003).
Pre-pregnancy SUA levels - and particularly the SUA/SCr ratio - were significantly associated with GDM among women undergoing ART.
随着全球生活方式的持续改变和经济发展，高尿酸血症的患病率稳步上升。血清尿酸（SUA）水平升高与妊娠期糖尿病（GDM）有关；然而，这种关系尚未在接受辅助生殖技术（ART）的女性中进行专门评估。因此，本研究旨在分析ART女性孕前SUA以及SUA与血清肌酐（SCr）比值与GDM之间的关系。
本回顾性队列研究在中国湖南长沙中信湘雅生殖与遗传医院进行，纳入了2017年至2018年间接受首次ART治疗的1027名女性。在任何ART程序之前的基线访视期间测量SUA水平，并根据口服葡萄糖耐量试验的筛查结果记录GDM发病率。
1027例患者中有172例（16.7%）被诊断为GDM。比较SUA五分位数时，观察到GDM发病率以及其他几个参数（包括孕前体重、BMI、血糖、血压、SCr、血脂参数、抗苗勒管激素、卵泡刺激素和睾酮）存在显著差异。在多变量分析中调整潜在混杂因素后，SUA与GDM发病率独立相关（OR 1.004， = 0.003）。此外，SUA/SCr比值显示出更强的相关性（OR 1.226， = 0.003）。
在接受ART的女性中，孕前SUA水平——尤其是SUA/SCr比值——与GDM显著相关。
