Andersen B R, McAninch J R, Patterson R
Clin Exp Immunol. 1971 Feb;8(2):263-9.
A survey of precipitating activity against dinitrophenyl (DNP) conjugated proteins, and a number of naturally occurring antigens was made in eighty-three sera from patients with multiple myeloma or Waldenströms macroglobulinaemia, thirty normal sera, and thirty-two sera from patients with a variety of non-neoplastic diseases. Three sera, an IgA myeloma serum, and two monoclonal IgM sera, had strong precipitating activity against DNP–protein conjugates. The precipitating activity was localized to the monoclonal proteins by immunoelectrophoresis and dextran gel chromatography. Weak anti-ascaris precipitin bands were noted in eight of the sera, but this activity probably was not a function of the monoclonal proteins. The IgA myeloma protein, which reacted with DNP conjugates, was also found to have a high rheumatoid factor activity.
对83份来自多发性骨髓瘤或瓦尔登斯特伦巨球蛋白血症患者的血清、30份正常血清以及32份来自各种非肿瘤性疾病患者的血清，进行了针对二硝基苯基（DNP）偶联蛋白和多种天然存在抗原的沉淀活性检测。三份血清，一份IgA骨髓瘤血清和两份单克隆IgM血清，对DNP - 蛋白偶联物具有强烈的沉淀活性。通过免疫电泳和葡聚糖凝胶色谱法，沉淀活性定位于单克隆蛋白。在8份血清中发现了微弱的抗蛔虫沉淀素带，但这种活性可能不是单克隆蛋白的作用。与DNP偶联物反应的IgA骨髓瘤蛋白也被发现具有高类风湿因子活性。
