Hannestad K
Clin Exp Immunol. 1969 May;4(5):555-78.
One M-component is described with anti-γG and anti-dinitrophenyl and anti-trinitrophenyl activity. The anti-hapten activity was shown by precipitation of DNP– and TNP–protein conjugates; this precipitation was specifically inhibited by the DNP–hapten. All of the M-component protein had these anti-hapten activities. The whole M-component also precipitated aggregated γG. DNP inhibited the anti-γG activity in precipitation and agglutination systems. Rheumatoid factors from sera of patients with classical rheumatoid arthritis exhibited similar, although weaker, reactivity with the haptens. The data indicate that rheumatoid factors cross-react with dinitrophenyl and trinitrophenyl groups.
一种M成分具有抗γG、抗二硝基苯基和抗三硝基苯基活性。通过DNP-和TNP-蛋白质缀合物的沉淀显示出抗半抗原活性；这种沉淀被DNP-半抗原特异性抑制。所有M成分蛋白都具有这些抗半抗原活性。整个M成分也能沉淀聚集的γG。DNP在沉淀和凝集系统中抑制抗γG活性。典型类风湿性关节炎患者血清中的类风湿因子与半抗原表现出相似但较弱的反应性。数据表明类风湿因子与二硝基苯基和三硝基苯基基团发生交叉反应。
