Feng Tongbao, Zhang Wuwen, Zhao Ting, Zhou Siyuan, Zhang Ping, Tang Liming
Department of Clinical Laboratory, the Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, China.
The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, China.
BMC Infect Dis. 2025 Sep 29;25(1):1195. doi: 10.1186/s12879-025-11591-1.
Human papillomavirus (HPV) transmission poses significant health risks, particularly in women. This study aims to detail the prevalence and characteristics of HPV infections both before and after surgical treatment in patients with cervical intraepithelial neoplasia (CIN) and cervical cancer.
We recruited 370 patients diagnosed with CIN or cervical cancer. The study first assessed the overall prevalence of preoperative HPV infections, analyzing variations across different age groups and histological diagnoses. We then investigated the relationships between postoperative HPV positivity rates and various factors including age, histological diagnoses, HPV genotypes, and the presence of multiple HPV infections. A comparative analysis was also conducted to observe the dynamics of HPV infections before and after cervical operations.
An overall HPV positivity rate of 97.0% was observed in patients diagnosed with CIN or cervical cancer, with HPV16, HPV52, HPV58, HPV33, HPV51, and HPV18 being the most prevalent genotypes. The distribution of HPV infection varied significantly by age and histological diagnosis. Notably, the prevalence of HPV16 showed significant differences across age and histological diagnoses groups. Among the 282 patients who underwent surgical treatment, 40.1% remained HPV positive postoperatively, with those aged ≥ 60 years and those with multiple HPV infections showing higher rates of postoperative HPV positivity.
The findings confirm the strong association between high-risk HPV infection and the development of CIN and cervical cancer. They also highlight the need for tailored approaches in the postoperative management of HPV to prevent recurrence, offering new insights for improving screening and treatment strategies.
人乳头瘤病毒（HPV）传播带来重大健康风险，对女性尤为如此。本研究旨在详细阐述宫颈上皮内瘤变（CIN）和宫颈癌患者手术治疗前后HPV感染的患病率及特征。
我们招募了370例被诊断为CIN或宫颈癌的患者。该研究首先评估术前HPV感染的总体患病率，分析不同年龄组和组织学诊断之间的差异。然后，我们调查术后HPV阳性率与年龄、组织学诊断、HPV基因型及多种HPV感染情况等各种因素之间的关系。还进行了对比分析，以观察宫颈手术后HPV感染的动态变化。
在被诊断为CIN或宫颈癌的患者中，总体HPV阳性率为97.0%，其中HPV16、HPV52、HPV58、HPV33、HPV51和HPV18是最常见的基因型。HPV感染的分布因年龄和组织学诊断而异。值得注意的是，HPV16的患病率在不同年龄组和组织学诊断组之间存在显著差异。在接受手术治疗的282例患者中，40.1%术后仍为HPV阳性，年龄≥60岁的患者和有多种HPV感染的患者术后HPV阳性率更高。
研究结果证实了高危HPV感染与CIN和宫颈癌发生之间的密切关联。它们还强调了在HPV术后管理中采取针对性方法以预防复发的必要性，为改进筛查和治疗策略提供了新的见解。
