De Lean A, Labrie F
Am J Physiol. 1977 Sep;233(3):E235-9. doi: 10.1152/ajpendo.1977.233.3.E235.
Daily administration of estradiol benzoate (10 microgram/100 g body wt) to intact male rats led to a twofold increase of the plasma TSH (thyroid-stimulating hormone) response to thyrotropin-releasing hormone (TRH) after 4 and 7 days of treatment whereas the basal plasma TSH level was not affected. The basal plasma PRL concentration and the PRL response to TRH were both markedly increased by estrogen treatment. The TSH pituitary content remained unchanged, whereas the PRL pituitary content increased in parallel with the effect on PRL secretion. Treatment with estrogens for 1 wk sensitized the TSH secretory response to low doses of TRH (10 ng), whereas no significant effect on the response was found at high doses of the neurohormone. The present data show that the stimulatory effect of estrogens on the TSH response to TRH is due to true sensitization of the thyrotrophs to the action of the neurohormone, whereas that on prolactin secretion can result partly from increased pituitary prolactin content.
给完整的雄性大鼠每日注射苯甲酸雌二醇（10微克/100克体重），在治疗4天和7天后，血浆促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）的反应增加了两倍，而基础血浆TSH水平未受影响。雌激素治疗使基础血浆催乳素浓度和催乳素对TRH的反应均显著增加。垂体促甲状腺激素含量保持不变，而垂体催乳素含量的增加与对催乳素分泌的影响平行。用雌激素治疗1周可使促甲状腺激素对低剂量TRH（10纳克）的分泌反应敏感，而在高剂量神经激素时未发现对该反应有显著影响。目前的数据表明，雌激素对促甲状腺激素对TRH反应的刺激作用是由于促甲状腺细胞对神经激素作用的真正敏感化，而对催乳素分泌的刺激作用部分可能是由于垂体催乳素含量增加。
