We have established that danazol is an orally active pituitary gonadotrophin inhibitory agent devoid of oestrogenic and progestational activity. This steroid has weak, impeded androgenic activity. Danazol is unique in possessing such a profound separation of pituitary gonadotrophin inhibitory activity from overt sex hormone activity. Separate studies have shown that danazol is antiandrogenic, anti-progestational and antioestrogenic. Extensive toxicological studies have established the safety of this steroid. Lastly, the metabolic studies provide convincing evidence that danazol is the active steroid.
我们已经确定，达那唑是一种口服活性的垂体促性腺激素抑制剂，不具有雌激素和孕激素活性。这种甾体具有微弱的、受阻的雄激素活性。达那唑的独特之处在于，其垂体促性腺激素抑制活性与明显的性激素活性有如此显著的分离。单独的研究表明，达那唑具有抗雄激素、抗孕激素和抗雌激素作用。广泛的毒理学研究已证实这种甾体的安全性。最后，代谢研究提供了令人信服的证据，证明达那唑是活性甾体。
Zotero 插件