Lund J S, Boothe R G, Lund R D
J Comp Neurol. 1977 Nov 15;176(2):149-88. doi: 10.1002/cne.901760203.
The morphological maturation of several varieties of neurons of cortical area 17 have been followed in Golgi Rapid preparations from Macaque monkeys ranging in age from fetal day 127 to maturity. A developmental sequence common to all varieties of neuron is described. Maturation occurs at the same rate at all cortical depths and appears to relate to the size of the neuron rather than to factors such as generation time, arrival at a final laminar position or cell type. The characteristic laminar patterns of cell type distribution and the specific axonal and dendritic arborisations seen in the adult are generated in the earliest stages of growth and do not occur as the result of elimination from a wider, less precise, distribution. During the period from birth to postnatal week 8 a marked increase in the numbers of dendritic spines is seen in all varieties of neuron including those which will be spine-free in the adult. Following this period an equally marked reduction in spine numbers occurs, initially rapid but continuing at a slower rate even nine months postnatally. Possible relationships between these postnatal dendritic spine changes and the extreme sensitivity of the system to visual input during the early postnatal weeks are discussed.
在年龄从胎儿第127天到成年的猕猴的高尔基快速染色标本中，对17区几种神经元的形态成熟过程进行了追踪。描述了所有神经元种类共有的发育序列。成熟在所有皮质深度以相同速率发生，并且似乎与神经元的大小有关，而不是与诸如生成时间、到达最终层位或细胞类型等因素有关。成年期所见的细胞类型分布的特征性层状模式以及特定的轴突和树突分支在生长的最早阶段就已形成，并非是从更广泛、更不精确的分布中消除的结果。在从出生到出生后第8周期间，在所有神经元种类中都观察到树突棘数量显著增加，包括那些在成年期将无棘的神经元。在此期间之后，树突棘数量同样显著减少，最初很快，但即使在出生后九个月仍以较慢速度持续减少。讨论了这些出生后树突棘变化与出生后早期该系统对视觉输入的极端敏感性之间可能的关系。
