手术程序可延长杜兴氏肌营养不良症患者的行走时间。
SURGICAL PROCEDURES PROLONG AMBULATION IN PATIENTS WITH DUCHENNE MUSCULAR DYSTROPHY.
作者信息
Nordon David Gonçalves, Reis Felipe Cruz Caetano Dos, Santos Carlos Alberto Dos, Paula Adilson DE, Resende Maria Bernadete Dutra DE, Grangeiro Patricia Moreno
机构信息
. Universidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas (HCFMUSP), Instituto de Ortopedia e Traumatologia, Centro Integrado de Neuro-ortopedia, Sao Paulo, SP, Brazil.
出版信息
Acta Ortop Bras. 2025 Oct 13;33(spe2):e287732. doi: 10.1590/1413-785220253302e287732. eCollection 2025 Sep.
OBJECTIVE
The aim of this study was to evaluate the effect of surgical procedures on maintaining ambulation for Duchenne patients.
METHODS
This retrospective cohort study evaluated 35 patients for whom surgery was recommended at our institution from 2012 to 2020.
RESULTS
Twenty-seven patients were operated on before gait loss, and eight after. In this study, surgical treatment allowed recovery and prolongation of gait for 38.6 months, on average. The sooner the surgery was performed, the better the results were; logistic regression analysis showed that each day of delay after gait loss decreased the chances of success by 0.2%. The optimal interval for intervention was up to 12 months after gait loss.
CONCLUSION
Our results thus corroborate the evidence that surgical interventions are beneficial for these patients and suggest a not previously described time window for achieving better outcomes. Level of Evidence lll; Retrospective, Comparative Study of Surgical Interventions.
目的
本研究旨在评估手术程序对杜兴氏病患者保持行走能力的影响。
方法
这项回顾性队列研究评估了2012年至2020年在我们机构被建议进行手术的35例患者。
结果
27例患者在步态丧失前接受了手术，8例在步态丧失后接受了手术。在本研究中，手术治疗使步态平均恢复并延长了38.6个月。手术进行得越早，效果越好；逻辑回归分析表明，步态丧失后每延迟一天，成功的机会就降低0.2%。最佳干预间隔是在步态丧失后12个月内。
结论
因此，我们的结果证实了手术干预对这些患者有益的证据，并提出了一个此前未描述的可实现更好结果的时间窗。证据等级III；手术干预的回顾性、比较性研究。
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