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临床前效应:习得行为。

Preclinical effects: learned behavior.

作者信息

Ferraro D P

出版信息

NIDA Res Monogr. 1977 Jul(14):103-17.

PMID:411038
Abstract

A review of the previous Marihuana and Health Reports (1971-1975) reveals that an extensive array of experimental procedures and contexts have been used to study the effects of cannabinoids on the performance of learned behavior in animals. These preclinical behavioral experiments have provided a framework for, and guided the design of, subsequent human experimentation. Compared to previous years, only a few experiments pertaining to cannabinoids and learned behavior have appeared during the past two years. By and large these more recent experiments confirm previous findings; no particularly novel procedures have been explored nor have there been dramatically unpredictable results. In part, the decrease in activity in cannabinoid preclinical animal research on learned behavior indicates an increase in human cannabinoid-learning investigations. Several detailed taxonomies of learned behavior are possible. However, for the purposes of the present report, learned behaviors will be categorized into those involving: avoidance learning and aversive control; reinforcement schedules and maze learning; and discrimination learning.

摘要

对之前的《大麻与健康报告》(1971 - 1975年)进行回顾发现,人们已采用大量的实验程序和环境来研究大麻素对动物习得行为表现的影响。这些临床前行为实验为后续人体实验提供了框架并指导了其设计。与前几年相比,在过去两年中,仅有少数关于大麻素与习得行为的实验出现。总体而言,这些较新的实验证实了先前的研究结果;既没有探索特别新颖的程序,也没有出现极具不可预测性的结果。在一定程度上,大麻素临床前动物习得行为研究活跃度的下降表明人体大麻素学习研究有所增加。习得行为有几种详细的分类方法。然而,就本报告而言,习得行为将被分类为涉及以下方面的行为:回避学习与厌恶控制;强化程序与迷宫学习;以及辨别学习。

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