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中央离心性瘢痕性脱发:皮肤科住院医师和主治医师治疗实践的调查

Central Centrifugal Cicatricial Alopecia: A Survey of Treatment Practices Among Dermatology Residents and Attending Physicians.

作者信息

Choi Janet, Ilan Isabelle, Tian Jin Ning, Balazic Eliza, Nwankwo Christy, Kobets Kseniya

机构信息

Division of Dermatology, Albert Einstein College of Medicine, Bronx, USA.

Ronald O. Perelman Department of Dermatology, New York University (NYU) Grossman School of Medicine, New York, USA.

出版信息

Cureus. 2025 Sep 20;17(9):e92780. doi: 10.7759/cureus.92780. eCollection 2025 Sep.

Abstract

Introduction Central centrifugal cicatricial alopecia (CCCA) is a type of primary scarring alopecia characterized by hair loss on the vertex of the scalp. While treatment often focuses on reducing inflammation, no established standard of care exists. Early diagnosis and intervention are critical, as advanced stages with permanent follicular scarring are challenging to treat. Our study aims to assess CCCA treatment practices and provider confidence among dermatology residents and attendings in an urban academic setting. We further compare these real-world practices with existing literature. Methods We conducted a cross-sectional survey study of the commonly prescribed/recommended treatments for CCCA in 31 residents and attending physicians at two dermatology programs. Of those, 26 indicated that they see patients with CCCA, comprising 17 residents and nine attending physicians. Results Overall, the most frequently utilized therapies for CCCA were topical corticosteroids (TCS) (n = 26), designated as first-line by 90.5% of users, topical minoxidil (n = 24), used first-line by 77.3%, and intralesional corticosteroids (n = 24), used first-line by 65% of users. Oral tetracyclines were used by only 56% (n = 14) of respondents. Discussion Our findings mostly align with the current recommendations in the literature, focusing on reducing inflammation with topical and intralesional corticosteroids. Interestingly, topical minoxidil was used first-line by most respondents, possibly reflecting its greater accessibility to our patient population. The discrepancies in our findings may be reflective of variability in provider comfort in CCCA management, concern for side effects of systemic treatments, and presentations of later, "burnt-out" stages of CCCA.

摘要

引言

中心离心性瘢痕性秃发(CCCA)是一种原发性瘢痕性秃发,其特征为头皮顶部脱发。虽然治疗通常侧重于减轻炎症,但尚无既定的标准治疗方案。早期诊断和干预至关重要,因为出现永久性毛囊瘢痕的晚期阶段治疗具有挑战性。我们的研究旨在评估城市学术环境中皮肤科住院医师和主治医生对CCCA的治疗实践以及他们的信心。我们还将这些实际做法与现有文献进行比较。

方法

我们对两个皮肤科项目的31名住院医师和主治医生进行了一项横断面调查研究,调查了CCCA常用的处方/推荐治疗方法。其中,26人表示他们诊治过CCCA患者,包括17名住院医师和9名主治医生。

结果

总体而言,CCCA最常用的治疗方法是外用皮质类固醇(TCS)(n = 26),90.5%的使用者将其指定为一线治疗药物;外用米诺地尔(n = 24),77.3%的使用者将其作为一线治疗药物;皮损内注射皮质类固醇(n = 24),65%的使用者将其作为一线治疗药物。只有56%(n = 14)的受访者使用口服四环素。

讨论

我们的研究结果大多与文献中的当前建议一致,重点是使用外用和皮损内注射皮质类固醇减轻炎症。有趣的是,大多数受访者将外用米诺地尔作为一线治疗药物,这可能反映出我们的患者群体更容易获得该药物。我们研究结果中的差异可能反映了提供者在CCCA管理方面的舒适度差异、对全身治疗副作用的担忧以及CCCA后期“耗竭”阶段的表现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d843/12536754/0e0907d540eb/cureus-0017-00000092780-i01.jpg

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