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用于在复杂导管解剖结构中进行稳健腔内导航和高径向力支架输送的模块化磁性微型机器人系统。

Modular magnetic microrobot system for robust endoluminal navigation and high-radial force stent delivery in complex ductal anatomy.

作者信息

Su Lin, Jin Dongdong, Xia Neng, Hao Bo, Jiang Yihang, Wang Qinglong, Yang Haojin, Wang Xin, Chan Kai Fung, Ma Xing, Chung Jacqueline Pui Wah, Chiu Philip Wai Yan, Zhang Li

机构信息

Department of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.

School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong 518055, China.

出版信息

Sci Adv. 2025 Oct 24;11(43):eady4339. doi: 10.1126/sciadv.ady4339. Epub 2025 Oct 22.

Abstract

Endoluminal stent implantation is a common intervention strategy for treating obstructive lesions, but conventional delivery systems struggle to reach deep, tortuous ducts. To overcome this limitation, we present a magnetically controlled microrobot that integrates two functional modules: a magnetic actuation (MA) module for agile navigation and an ultrasound-responsive self-expanding stent module (ST module) for lesion-specific dilation. The system uses a dynamically tunable assembly mechanism governed by rotational direction enabling integrated locomotion (clockwise) and on-demand module separation (counterclockwise) at stenotic sites. The platform is compatible with intraoperative ultrasound, allowing real-time navigation and thermally triggered expansion in physiological environments. By synergizing programmable magnetic actuation, ultrasound-mediated expansion, and clinical workflow compatibility, the robot can navigate tortuous phantom ducts, achieving controlled stent deployment within 3 seconds and complete expansion within 30 seconds, permitting minimally invasive treatment of biliary strictures. This work advances microrobotic stent delivery by overcoming key barriers to clinical translation in endoluminal interventions.

摘要

腔内支架植入是治疗阻塞性病变的常见干预策略,但传统的输送系统难以到达深部、迂曲的导管。为了克服这一局限性,我们提出了一种磁控微型机器人,它集成了两个功能模块:一个用于灵活导航的磁驱动(MA)模块和一个用于病变特异性扩张的超声响应自膨胀支架模块(ST模块)。该系统采用由旋转方向控制的动态可调组装机制,能够在狭窄部位实现集成运动(顺时针)和按需模块分离(逆时针)。该平台与术中超声兼容,可在生理环境中进行实时导航和热触发扩张。通过将可编程磁驱动、超声介导的扩张和临床工作流程兼容性相结合,该机器人可以在迂曲的模拟导管中导航,在3秒内实现可控的支架部署,并在30秒内完成完全扩张,从而实现对胆管狭窄的微创治疗。这项工作通过克服腔内干预临床转化的关键障碍,推动了微型机器人支架输送技术的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ae2/12542956/0ff2496f218e/sciadv.ady4339-f1.jpg

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