Kersey J H, Gatti R A, Good R A, Aaronson S A, Todaro G J
Proc Natl Acad Sci U S A. 1972 Apr;69(4):980-2. doi: 10.1073/pnas.69.4.980.
Skin fibroblasts were cultured from 15 patients with primary immunodeficiency diseases associated with a high cancer risk, including sex-linked agammaglobulinemia, IgA deficiency, variable immunodeficiency, ataxia-telangiectasia (cerebellar malfunction and abnormalities of blood vessels and immune response), Wiskott-Aldrich syndrome (low platelet count, eczema, and abnormal immune mechanism), and severe combined system (cellular and humoral) immunodeficiency. Fourteen of 15 cell strains were found to have low or regular susceptibility to transformation with the tumor virus, simian virus 40. The data are consistent with the view that the frequent occurrence of malignancy in patients with primary immunodeficiency is due to abnormalities of the immunologic surveillance mechanism.
从15例原发性免疫缺陷病患者中培养出皮肤成纤维细胞，这些患者有患癌高风险，包括性连锁无丙种球蛋白血症、IgA缺乏症、可变免疫缺陷、共济失调毛细血管扩张症（小脑功能障碍以及血管和免疫反应异常）、威斯科特-奥尔德里奇综合征（血小板计数低、湿疹以及免疫机制异常）和严重联合系统（细胞和体液）免疫缺陷。15个细胞株中有14个被发现对肿瘤病毒猿猴病毒40转化的敏感性较低或正常。这些数据与以下观点一致，即原发性免疫缺陷患者中恶性肿瘤的频繁发生是由于免疫监视机制异常。
