Thomas W R, Turner K J, Eadie M E, Yadav M
Immunology. 1972 Mar;22(3):401-16.
The quokka () a macropod marsupial endemic to Western Australia forms circulating antibodies to bacteriophage ΦX174, flagella, sheep erythrocytes and bovine serum albumin. The kinetics of antibody production in the primary and secondary responses suggest that the immunological capacity of the quokka is between that of eutherians and the lower vertebrates. Three classes of antibody, macroglobulin, IgG and a low molecular weight antibody (80,000 daltons) were produced. However, the production of low molecular weight antibody was dependent upon the nature of the antigen. Evidence is presented to suggest that while the IgG and low molecular weight classes of antibody share common antigenic determinants on the heavy chains, they are independent entities. A low molecular weight degradation product of IgG accumulated in immune sera but the low molecular weight antibody is neither a degradation nor an anabolic byproduct of IgG immunoglobulin.
短尾矮袋鼠是西澳大利亚特有的有袋类有袋动物,它能形成针对噬菌体ΦX174、鞭毛、绵羊红细胞和牛血清白蛋白的循环抗体。初次和二次应答中抗体产生的动力学表明,短尾矮袋鼠的免疫能力介于真兽类和低等脊椎动物之间。产生了三类抗体,即巨球蛋白、免疫球蛋白G(IgG)和一种低分子量抗体(80,000道尔顿)。然而,低分子量抗体的产生取决于抗原的性质。有证据表明,虽然IgG和低分子量类抗体在重链上有共同的抗原决定簇,但它们是独立的实体。IgG的一种低分子量降解产物在免疫血清中积累,但低分子量抗体既不是IgG免疫球蛋白的降解产物也不是合成代谢副产物。