Manzke H, Dörner K, Grünitz J
Acta Paediatr Scand. 1977 Nov;66(6):713-7. doi: 10.1111/j.1651-2227.1977.tb07977.x.
The concentration of hypoxanthine, xanthine and uric acid in the first 24-h urine of 105 newborn infants was measured densitometrically by thin-layer chromatography. 45 of them had moderate or severe perinatal complications. Among these newborns, 26 infants with perinatal complications (58%) and 4 infants without perinatal complications (7%) had an elevated urinary excretion rate of hypoxanthine. Urinary xanthine was not increased, uric acid was slightly higher in the group of infants with perinatal complication. It seems that a crucial mark is involved, if the rate of hypoxanthine exceed 15% of the total urinary oxypurine excretion, or, if related to urinary creatinine, more than 0.075 mumol hypoxanthine/mumol creatinine. Apparently, with hypoxic newborns increased values of urinary hypoxanthine excretion can be used to quantify the lack of oxygen retrospectively.
采用薄层色谱光密度法测定了105例新生儿出生后24小时内尿液中次黄嘌呤、黄嘌呤和尿酸的浓度。其中45例有中度或重度围产期并发症。在这些新生儿中，26例有围产期并发症的婴儿（58%）和4例无围产期并发症的婴儿（7%）次黄嘌呤尿排泄率升高。尿黄嘌呤未增加，围产期并发症婴儿组尿酸略高。似乎有一个关键指标，如果次黄嘌呤率超过尿中氧嘌呤总排泄量的15%，或者与尿肌酐相关，超过0.075μmol次黄嘌呤/μmol肌酐。显然，对于缺氧新生儿，尿次黄嘌呤排泄值的增加可用于回顾性地量化缺氧程度。
