Wodzicki A M, Coopland A T
Can Med Assoc J. 1972 Jul 8;107(1):38-41.
There is an apparent discrepancy between the effects on the hemostatic mechanism of synthetic progestins alone and synthetic progestins in combination with synthetic estrogens. Coagulation studies were carried out on 21 patients treated with chlormadinone acetate 0.5 mg. on a continuous daily basis for 12 weeks in order to determine its effects on hemostasis. Unlike the standard estrogen/progestin contraceptive agents, this synthetic progestin appears to have no effect on the coagulation system as determined by standard laboratory tests.
单独使用合成孕激素与合成孕激素联合合成雌激素对止血机制的影响之间存在明显差异。对21例每日连续服用0.5毫克醋酸氯地孕酮12周的患者进行了凝血研究,以确定其对止血的影响。与标准的雌激素/孕激素避孕药不同,通过标准实验室检测确定,这种合成孕激素似乎对凝血系统没有影响。